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Literature summary extracted from

  • Pircher, H.; von Grafenstein, S.; Diener, T.; Metzger, C.; Albertini, E.; Taferner, A.; Unterluggauer, H.; Kramer, C.; Liedl, K.R.; Jansen-Duerr, P.
    Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase (2015), J. Biol. Chem., 290, 6755-6762 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.112 expressed in Mus musculus Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.112 D102A/R106A the mutant shows about 3% of wild type activity Homo sapiens
4.1.1.112 E33A the mutant shows about 40% of wild type activity Homo sapiens
4.1.1.112 H30A the mutant shows about 20% of wild type activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.112 oxalate potent competitive inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.112 0.032
-
 oxaloacetate at pH 7.4 and 25°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.112 fumarylpyruvate + H2O Homo sapiens
-
 fumarate + pyruvate + H+
-
 ?
4.1.1.112 oxaloacetate + H+ Homo sapiens
-
 pyruvate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.112 Homo sapiens Q6P587
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.112
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.112 fumarylpyruvate + H2O
-
 Homo sapiens fumarate + pyruvate + H+
-
 ?
4.1.1.112 oxaloacetate + H+
-
 Homo sapiens pyruvate + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.112 homodimer 2 * 29000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
4.1.1.112 FAH domain-containing protein 1
-
 Homo sapiens
4.1.1.112 FAHD1
-
 Homo sapiens
4.1.1.112 fumarylacetoacetate hydrolase domain-containing protein 1
-
 Homo sapiens
4.1.1.112 ODx
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.112 0.001
-
 oxalate at pH 7.4 and 25°C Homo sapiens