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Literature summary extracted from

  • Andreotti, G.; Cabeza de Vaca, I.; Poziello, A.; Monti, M.C.; Guallar, V.; Cubellis, M.V.
    Conformational response to ligand binding in phosphomannomutase2 insights into inborn glycosylation disorder (2014), J. Biol. Chem., 289, 34900-34910 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.4.2.8 alpha-D-Glucose 1,6-bisphosphate
-
 Homo sapiens
5.4.2.8 alpha-D-mannose 1,6-bisphosphate
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.2.8 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
5.4.2.8 F119L monomeric mutant Homo sapiens
5.4.2.8 R141H the mutation lowers activity to approximately one hundredth of that of wild type enzyme Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.4.2.8 Homo sapiens O15305
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.2.8 DEAE-Sepharose column chromatography and Superdex 75 gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.2.8 alpha-D-glucose 1-phosphate
-
 Homo sapiens alpha-D-glucose 6-phosphate
-
 r
5.4.2.8 alpha-D-mannose 1-phosphate
-
 Homo sapiens alpha-D-mannose 6-phosphate
-
 r

Subunits

EC Number Subunits Comment Organism
5.4.2.8 homodimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
5.4.2.8 phosphomannomutase2
-
 Homo sapiens
5.4.2.8 PMM2
-
 Homo sapiens