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Literature summary extracted from

  • Wang, Y.T.; Missiakas, D.; Schneewind, O.
    GneZ, a UDP-GlcNAc 2-epimerase, is required for S-layer assembly and vegetative growth of Bacillus anthracis (2014), J. Bacteriol., 196, 2969-2978 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.1.3.14 gene gneY, DNA and amino acid sequence determination and analysis, genetic structure, sequence comparisons Bacillus anthracis
5.1.3.14 gene gneYZ, DNA and amino acid sequence determination and analysis, genetic structure, sequence comparisons Bacillus anthracis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.3.14 UDP-N-acetyl-alpha-D-glucosamine Bacillus anthracis
-
 UDP-N-acetyl-alpha-D-mannosamine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.1.3.14 Bacillus anthracis Q81K32
-
-
5.1.3.14 Bacillus anthracis Q81X16
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.3.14 UDP-N-acetyl-alpha-D-glucosamine
-
 Bacillus anthracis UDP-N-acetyl-alpha-D-mannosamine
-
 r

Synonyms

EC Number Synonyms Comment Organism
5.1.3.14 bas5048
-
 Bacillus anthracis
5.1.3.14 bas5117
-
 Bacillus anthracis
5.1.3.14 GneY
-
 Bacillus anthracis
5.1.3.14 GneZ
-
 Bacillus anthracis
5.1.3.14 UDP-GlcNAc 2-epimerase
-
 Bacillus anthracis

General Information

EC Number General Information Comment Organism
5.1.3.14 evolution Bacillus anthracis gneY and gneZ encode nearly identical UDP-GlcNAc 2-epimerase enzymes that catalyze the reversible conversion of UDPGlcNAc and UDP-ManNAc Bacillus anthracis
5.1.3.14 physiological function GneZ, a UDP-GlcNAc 2-epimerase, is required for S-layer assembly and vegetative growth of Bacillus anthracis. Gene gneZ, but not gneY, is required for Bacillus anthracis vegetative growth, rod cell shape, S-layer assembly, and synthesis of pyruvylated secondary cell wall polysaccharide (SCWP). Nevertheless, inducible expression of gneY alleviates all the defects associated with the gneZ mutant. In contrast to vegetative growth, neither germination of Bacillus anthracis spores nor the formation of spores in mother cells require UDP-GlcNAc 2-epimerase activity. UDP-GlcNAc 2-epimerase enzymes have been shown to be required for the attachment of the phage lysin PlyG with the bacterial envelope and for bacterial growth. UDG-GlcNAc 2-epimerase activity, i.e., the expression of either gneY or gneZ, is not required for B. anthracis spore formation Bacillus anthracis