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Literature summary extracted from

  • Lenis, Y.Y.; Johnson, G.A.; Wang, X.; Tang, W.W.; Dunlap, K.A.; Satterfield, M.C.; Wu, G.; Hansen, T.R.; Bazer, F.W.
    Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep (2018), J. Anim. Sci. Biotechnol., 9, 10 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.17 additional information in vivo knockdown of translation of ODC1 and ADC (EC 4.1.1.19) mRNAs individually and in combination. Double knockdown of ODC1 and ADC (MAO-ODC1:ADC) results in two phenotypes (a or b) of conceptuses: 33% of conceptuses appear to be morphologically and functionally normal (phenotype a) and 67% of the conceptuses present an abnormal morphology and functionality (phenotype b). Furthermore, MAO-ODC1:ADC (a) conceptuses have greater tissue concentrations of agmatine, putrescine, and spermidine than MAO control conceptuses, while AO-ODC1:ADC (b) conceptuses only have greater tissue concentrations of agmatine. Uterine flushes from ewes with MAO-ODC1:ADC (a) have greater amounts of arginine, aspartate, tyrosine, citrulline, lysine, phenylalanine, isoleucine, leucine, and glutamine, while uterine flushes of ewes with MAO-ODC1:ADC (b) conceptuses have lower amount of putrescine, spermidine, spermine, alanine, aspartate, glutamine, tyrosine, phenylalanine, isoleucine, leucine, and lysine. Phenotypes, overview Ovis aries
4.1.1.19 additional information in vivo knockdown of translation of ODC1 (EC 4.1.1.17) and ADC mRNAs individually and in combination. Double knockdown of ODC1 and ADC (MAO-ODC1:ADC) results in two phenotypes (a or b) of conceptuses: 33% of conceptuses appear to be morphologically and functionally normal (phenotype a) and 67% of the conceptuses present an abnormal morphology and functionality (phenotype b). Furthermore, MAO-ODC1:ADC (a) conceptuses have greater tissue concentrations of agmatine, putrescine, and spermidine than MAO control conceptuses, while AO-ODC1:ADC (b) conceptuses only have greater tissue concentrations of agmatine. Uterine flushes from ewes with MAO-ODC1:ADC (a) have greater amounts of arginine, aspartate, tyrosine, citrulline, lysine, phenylalanine, isoleucine, leucine, and glutamine, while uterine flushes of ewes with MAO-ODC1:ADC (b) conceptuses have lower amount of putrescine, spermidine, spermine, alanine, aspartate, glutamine, tyrosine, phenylalanine, isoleucine, leucine, and lysine. Phenotypes, overview Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.17 L-ornithine Ovis aries
-
 putrescine + CO2
-
 ?
4.1.1.17 L-ornithine Ovis aries Rambouillet
-
 putrescine + CO2
-
 ?
4.1.1.19 L-arginine Ovis aries
-
 agmatine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.17 Ovis aries W5Q1G7
-
-
4.1.1.17 Ovis aries Rambouillet W5Q1G7
-
-
4.1.1.19 Ovis aries
-
 Rambouillet
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.17 embryo
-
 Ovis aries
-
4.1.1.17 fetus
-
 Ovis aries
-
4.1.1.17 placenta
-
 Ovis aries
-
4.1.1.17 trophectoderm
-
 Ovis aries
-
4.1.1.19 embryo
-
 Ovis aries
-
4.1.1.19 fetus
-
 Ovis aries
-
4.1.1.19 placenta
-
 Ovis aries
-
4.1.1.19 trophectoderm
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.17 L-ornithine
-
 Ovis aries putrescine + CO2
-
 ?
4.1.1.17 L-ornithine
-
 Ovis aries Rambouillet putrescine + CO2
-
 ?
4.1.1.19 L-arginine
-
 Ovis aries agmatine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.17 ODC1
-
 Ovis aries
4.1.1.19 ADC
-
 Ovis aries

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.17 pyridoxal 5'-phosphate
-
 Ovis aries

General Information

EC Number General Information Comment Organism
4.1.1.17 malfunction double knockdown of ODC1 and ADC, EC 4.1.1.19, (MAO-ODC1:ADC) results in two phenotypes of conceptuses (a or b): 33% of conceptuses appear to be morphologically and functionally normal (phenotype a) and 67% of the conceptuses present an abnormal morphology and functionality (phenotype b). Furthermore, MAO-ODC1:ADC (a) conceptuses have greater tissue concentrations of agmatine, putrescine, and spermidine than MAO control conceptuses, while AO-ODC1:ADC (b) conceptuses only have greater tissue concentrations of agmatine. Uterine flushes from ewes with MAO-ODC1:ADC (a) have greater amounts of arginine, aspartate, tyrosine, citrulline, lysine, phenylalanine, isoleucine, leucine, and glutamine, while uterine flushes of ewes with MAO-ODC1:ADC (b) conceptuses have lower amount of putrescine, spermidine, spermine, alanine, aspartate, glutamine, tyrosine, phenylalanine, isoleucine, leucine, and lysine. In vivo knockdown of translation of ODC1 and ADC mRNAs individually and in combination affects the abundance of polyamines in the uterine lumen Ovis aries
4.1.1.17 physiological function functional roles of ornithine decarboxylase and arginine decarboxylase (EC 4.1.1.19) during the peri-implantation period of pregnancy in sheep. Polyamines stimulate DNA transcription and mRNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells. Therefore, they are essential for development and survival of conceptuses (embryo/fetus and placenta). The ovine conceptus produces polyamines via classical and non-classical pathways. In the classical pathway, arginine (Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase (ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine. In the non-classical pathway, Arg is converted to agmatine (Agm) by arginine decarboxylase (ADC), and Agm is converted to putrescine by agmatinase (AGMAT) Ovis aries
4.1.1.19 malfunction double knockdown of ODC1 (EC 4.1.1.17) and ADC (MAO-ODC1:ADC) results in two phenotypes of conceptuses (a or b): 33% of conceptuses appear to be morphologically and functionally normal (phenotype a) and 67% of the conceptuses present an abnormal morphology and functionality (phenotype b). Furthermore, MAO-ODC1:ADC (a) conceptuses have greater tissue concentrations of agmatine, putrescine, and spermidine than MAO control conceptuses, while AO-ODC1:ADC (b) conceptuses only have greater tissue concentrations of agmatine. Uterine flushes from ewes with MAO-ODC1:ADC (a) have greater amounts of arginine, aspartate, tyrosine, citrulline, lysine, phenylalanine, isoleucine, leucine, and glutamine, while uterine flushes of ewes with MAO-ODC1:ADC (b) conceptuses have lower amount of putrescine, spermidine, spermine, alanine, aspartate, glutamine, tyrosine, phenylalanine, isoleucine, leucine, and lysine. In vivo knockdown of translation of ODC1 and ADC mRNAs individually and in combination affects the abundance of polyamines in the uterine lumen Ovis aries
4.1.1.19 physiological function functional roles of ornithine decarboxylase (EC 4.1.1.17) and arginine decarboxylase during the peri-implantation period of pregnancy in sheep. Polyamines stimulate DNA transcription and mRNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells. Therefore, they are essential for development and survival of conceptuses (embryo/fetus and placenta). The ovine conceptus produces polyamines via classical and non-classical pathways. In the classical pathway, arginine (Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase (ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine. In the non-classical pathway, Arg is converted to agmatine (Agm) by arginine decarboxylase (ADC), and Agm is converted to putrescine by agmatinase (AGMAT) Ovis aries