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Literature summary extracted from

  • Skovpen, Y.V.; Conly, C.J.; Sanders, D.A.; Palmer, D.R.
    Biomimetic design results in a potent allosteric inhibitor of dihydrodipicolinate synthase from Campylobacter jejuni (2016), J. Am. Chem. Soc., 138, 2014-2020 .
    View publication on PubMed

Application

EC Number Application Comment Organism
4.3.3.7 drug development the enzyme is a target for antibiotics Campylobacter jejuni
4.3.3.7 pharmacology the enzyme is a target for antibiotics Campylobacter jejuni

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.3.3.7 crystals are grown in a solution of 0.28 M sodium acetate, 30% PEG 4000, 0.1 M TRIS pH 8.5 using the hanging drop vapor diffusion method Campylobacter jejuni

Protein Variants

EC Number Protein Variants Comment Organism
4.3.3.7 Y110F the mutant enzyme is resistant to lysine inhibition Campylobacter jejuni

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.3.7 bislysine bislysine is a mixed partial inhibitor with respect to the first substrate, pyruvate, and a noncompetitive partial inhibitor with respect to L-aspartate-4-semialdehyde Campylobacter jejuni
4.3.3.7 L-lysine allosteric inhibitor Campylobacter jejuni

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.3.7 pyruvate + L-aspartate-4-semialdehyde Campylobacter jejuni
-
 (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.3.7 Campylobacter jejuni
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.3.7
-
 Campylobacter jejuni

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.3.7 pyruvate + L-aspartate-4-semialdehyde
-
 Campylobacter jejuni (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.3.3.7 DHDPS
-
 Campylobacter jejuni

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.3.3.7 0.0002
-
 bislysine pH 8.0, 25°C Campylobacter jejuni