EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.3.1.118 | crystallization of InhA with isoniazid-NADP bound and the structure of the complex is solved | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.118 | isoniazid | a pro-drug, which is oxidatively activated in vivo by the katG-encoded mycobacterial catalase peroxidase to generate an isonicotinoyl radical. This highly reactive species then reacts nonenzymatically with the cellular pyridine nucleotide coenzymes, NAD+ and NADP+, to generate 12 isonicotinoyl-NAD(P)+ adducts. Of these, the acyclic 4S isomer of isoniazid-NAD+ and the acyclic 4R isomer of isoniazid-NADP+ inhibit the inhA-encoded enoyl-ACP reductase | Mycobacterium tuberculosis | |
1.3.1.118 | isoniazid-NAD+ | - |
Mycobacterium tuberculosis | |
1.3.1.118 | isoniazid-NADP | competitive | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.118 | Mycobacterium tuberculosis | P9WGR1 | - |
- |
1.3.1.118 | Mycobacterium tuberculosis ATCC 25618 | P9WGR1 | - |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.1.118 | InhA | - |
Mycobacterium tuberculosis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.1.118 | 0.00013 | - |
isoniazid-NADP | pH 7.0, temperature not specified in the publication | Mycobacterium tuberculosis |