Literature summary extracted from

Furukawa, F.; Tseng, Y.C.; Liu, S.T.; Chou, Y.L.; Lin, C.C.; Sung, P.H.; Uchida, K.; Lin, L.Y.; Hwang, P.P.
Induction of phosphoenolpyruvate carboxykinase (PEPCK) during acute acidosis and its role in acid secretion by V-ATPase-expressing ionocytes (2015), Int. J. Biol. Sci., 11, 712-725 .

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.1.1.49	Danio rerio	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.1.1.49	larva	-	Danio rerio	-

Expression

EC Number	Organism	Comment	Expression
4.1.1.49	Danio rerio	expression increases in response to acid stress	up

General Information

EC Number	General Information	Comment	Organism
4.1.1.49	physiological function	Danio rerio larvae show increased V-ATPase-mediated acid secretion and transient expression of Pck1, in response to acid stress. Pck1 gene knockdown decreases the H+ secretion via V-ATPase, the effect is rescued by supplementation of glucose into the yolk. Pck1 knockdown does not affect glutamine/glutamate catalysis	Danio rerio

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Release 2023.1 (January 2023)