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Literature summary extracted from

  • Giroux, X.; MacNeill, S.A.
    Inhibiting NAD+-dependent DNA ligase activity with 2-(cyclopentyloxy)-5'-deoxyadenosine (CPOdA) offers a new tool for DNA replication and repair studies in the model archaeon Haloferax volcanii (2015), FEMS Microbiol. Lett., 362, pii: fnv181 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.2 2-(cyclopentyloxy)-5'-deoxyadenosine
-
 Haloferax volcanii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Haloferax volcanii
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.2 Haloferax volcanii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Haloferax volcanii (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.2 LigN
-
 Haloferax volcanii
6.5.1.2 NAD+-dependent DNA ligase
-
 Haloferax volcanii

Cofactor

EC Number Cofactor Comment Organism Structure
6.5.1.2 NAD+
-
 Haloferax volcanii