EC Number | Crystallization (Comment) | Organism |
---|---|---|
5.3.1.8 | structure complexed with inhibitor 5-phospho-D-arabinonhydrazide at 1.85 A resolution. Glu294 is the catalytic base that transfers a proton between the C1 and C2 carbon atoms of the substrate. The inhibitor shows bidentate coordination | Candida albicans |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.3.1.8 | 5-phospho-D-arabinonhydrazide | - |
Candida albicans |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
5.3.1.8 | 0.13 | - |
D-mannose 6-phosphate | pH not specified in the publication, temperature not specified in the publication | Candida albicans |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
5.3.1.8 | Zn2+ | The Zn binding mode of the 5-phospho-D-arabinonhydrazide inhibitor mimics the bidentate Zn coordination of substrate and high energy intermediate | Candida albicans |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.3.1.8 | Candida albicans | P34948 | - |
- |
5.3.1.8 | Candida albicans ATCC MYA-2876 | P34948 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.1.8 | D-Mannose 6-phosphate | - |
Candida albicans | D-Fructose 6-phosphate | - |
r | |
5.3.1.8 | D-Mannose 6-phosphate | - |
Candida albicans ATCC MYA-2876 | D-Fructose 6-phosphate | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.3.1.8 | Pmi1 | - |
Candida albicans |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
5.3.1.8 | 0.0017 | - |
5-phospho-D-arabinonhydrazide | pH not specified in the publication, temperature not specified in the publication | Candida albicans |