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Literature summary extracted from

  • Ahmad, L.; Plancqueel, S.; Dubosclard, V.; Lazar, N.; Ghattas, W.; Li de la Sierra-Gallay, I.; van Tilbeurgh, H.; Salmon, L.
    Crystal structure of phosphomannose isomerase from Candida albicans complexed with 5-phospho-D-arabinonhydrazide (2018), FEBS Lett., 592, 1667-1680 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.3.1.8 structure complexed with inhibitor 5-phospho-D-arabinonhydrazide at 1.85 A resolution. Glu294 is the catalytic base that transfers a proton between the C1 and C2 carbon atoms of the substrate. The inhibitor shows bidentate coordination Candida albicans

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.1.8 5-phospho-D-arabinonhydrazide
-
Candida albicans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.1.8 0.13
-
D-mannose 6-phosphate pH not specified in the publication, temperature not specified in the publication Candida albicans

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.3.1.8 Zn2+ The Zn binding mode of the 5-phospho-D-arabinonhydrazide inhibitor mimics the bidentate Zn coordination of substrate and high energy intermediate Candida albicans

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.8 Candida albicans P34948
-
-
5.3.1.8 Candida albicans ATCC MYA-2876 P34948
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.8 D-Mannose 6-phosphate
-
Candida albicans D-Fructose 6-phosphate
-
r
5.3.1.8 D-Mannose 6-phosphate
-
Candida albicans ATCC MYA-2876 D-Fructose 6-phosphate
-
r

Synonyms

EC Number Synonyms Comment Organism
5.3.1.8 Pmi1
-
Candida albicans

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.3.1.8 0.0017
-
5-phospho-D-arabinonhydrazide pH not specified in the publication, temperature not specified in the publication Candida albicans