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Literature summary extracted from

  • MacDonald, J.R.; Huang, A.D.; Loomes, K.M.
    Cellular degradation of 4-hydroxy-2-oxoglutarate aldolase leads to absolute deficiency in primary hyperoxaluria type 3 (2016), FEBS Lett., 590, 1467-1476 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.3.16 expressed in Escherichia coli BL21 (DE3) cells and HEK-293 cells Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.3.16 80000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.3.16 4-Hydroxy-2-oxoglutarate Homo sapiens
-
 Pyruvate + glyoxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.16 Homo sapiens Q86XE5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.16 4-Hydroxy-2-oxoglutarate
-
 Homo sapiens Pyruvate + glyoxylate
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.3.16 ? x * 32466, mass spectrometry Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
4.1.3.16 HOGA1
-
 Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.1.3.16 68
-
 melting temperature Homo sapiens

General Information

EC Number General Information Comment Organism
4.1.3.16 malfunction enzyme mutations ultimately lead to oxalate accumulation and stone formation in primary hyperoxaluria type 3 Homo sapiens