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Literature summary extracted from

  • Zamek-Gliszczynski, M.; Hoffmaster, K.; Nezasa, K.; Tallman, M.; Brouwer, K.
    Integration of hepatic drug transporters and phase II metabolizing enzymes Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites (2006), Eur. J. Pharm. Sci., 27, 447-486 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1] Mus musculus
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1] Homo sapiens
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1] Rattus norvegicus
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.3 Homo sapiens O15438
-
-
7.6.2.3 Homo sapiens O15439
-
-
7.6.2.3 Homo sapiens Q92887
-
-
7.6.2.3 Homo sapiens Q9UNQ0
-
-
7.6.2.3 Mus musculus
-
-
-
7.6.2.3 Mus musculus P04095
-
-
7.6.2.3 Mus musculus Q7TMS5
-
-
7.6.2.3 Mus musculus Q8VI47
-
-
7.6.2.3 Rattus norvegicus Q63120
-
-
7.6.2.3 Rattus norvegicus Q6QMG6
-
-
7.6.2.3 Rattus norvegicus Q80W57
-
-
7.6.2.3 Rattus norvegicus Q88563
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.3 Hep-G2 cell
-
 Homo sapiens
-
7.6.2.3 liver
-
 Mus musculus
-
7.6.2.3 liver
-
 Homo sapiens
-
7.6.2.3 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1]
-
 Mus musculus ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1]
-
 Homo sapiens ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1]
-
 Rattus norvegicus ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
7.6.2.3 ATP + H2O + leukotriene C4[side 1]
-
 Mus musculus ADP + phosphate + leukotriene C4[side 2]
-
 ?
7.6.2.3 ATP + H2O + leukotriene C4[side 1]
-
 Homo sapiens ADP + phosphate + leukotriene C4[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(acetaminophen)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(acetaminophen)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(acetaminophen)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(acetaminophen)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(arsenite)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(arsenite)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(arsenite)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(arsenite)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(arsenite)glutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + S-(arsenite)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(bimanyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(bimanyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(bimanyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(bimanyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(curcuminyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(curcuminyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(curcuminyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(curcuminyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(deoxyprostaglandin J2)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(deoxyprostaglandin J2)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(deoxyprostaglandin J2)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(deoxyprostaglandin J2)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(ethacrynic acid)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(ethacrynic acid)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(ethacrynic acid)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(ethacrynic acid)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(hydroxynonenyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(hydroxynonenyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(hydroxynonenyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(hydroxynonenyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(leukotriene C4)glutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + S-(leukotriene C4)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(methylfluorescinyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(methylfluorescinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(methylfluorescinyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(methylfluorescinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(methylmercury)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(methylmercury)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(methylmercury)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(methylmercury)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(methylmercury)glutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + S-(methylmercury)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(N-ethylmaleimidyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(N-ethylmaleimidyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(N-ethylmaleimidyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(N-ethylmaleimidyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(sulfobromophthaleinyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(sulfobromophthaleinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(sulfobromophthaleinyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(sulfobromophthaleinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-(sulfobromophthaleinyl)glutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + S-(sulfobromophthaleinyl)glutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-decylglutathione[side 1]
-
 Mus musculus ADP + phosphate + S-decylglutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-decylglutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-decylglutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-decylglutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + S-decylglutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-methylglutathione[side 1]
-
 Mus musculus ADP + phosphate + S-methylglutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-methylglutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-methylglutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-metolachloroglutathione[side 1]
-
 Mus musculus ADP + phosphate + S-metolachloroglutathione[side 2]
-
 ?
7.6.2.3 ATP + H2O + S-metolachloroglutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-metolachloroglutathione[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.3 ABCC2
-
 Homo sapiens
7.6.2.3 ABCC2
-
 Rattus norvegicus
7.6.2.3 ABCC2
-
 Mus musculus
7.6.2.3 ABCC3
-
 Homo sapiens
7.6.2.3 ABCC3
-
 Rattus norvegicus
7.6.2.3 ABCC3
-
 Mus musculus
7.6.2.3 ABCC4
-
 Mus musculus
7.6.2.3 ABCC4
-
 Homo sapiens
7.6.2.3 ABCC4
-
 Rattus norvegicus
7.6.2.3 ABCG2
-
 Homo sapiens
7.6.2.3 ABCG2
-
 Rattus norvegicus
7.6.2.3 ABCG2
-
 Mus musculus
7.6.2.3 BCRP
-
 Homo sapiens
7.6.2.3 BCRP
-
 Rattus norvegicus
7.6.2.3 BCRP
-
 Mus musculus
7.6.2.3 breast cancer resistance protein
-
 Mus musculus
7.6.2.3 breast cancer resistance protein
-
 Homo sapiens
7.6.2.3 breast cancer resistance protein
-
 Rattus norvegicus
7.6.2.3 MRP2
-
 Homo sapiens
7.6.2.3 MRP2
-
 Rattus norvegicus
7.6.2.3 MRP2
-
 Mus musculus
7.6.2.3 MRP3
-
 Homo sapiens
7.6.2.3 MRP3
-
 Rattus norvegicus
7.6.2.3 MRP3
-
 Mus musculus
7.6.2.3 MRP4
-
 Mus musculus
7.6.2.3 MRP4
-
 Homo sapiens
7.6.2.3 MRP4
-
 Rattus norvegicus
7.6.2.3 multidrug resistance-associated protein 2
-
 Homo sapiens
7.6.2.3 multidrug resistance-associated protein 2
-
 Rattus norvegicus
7.6.2.3 multidrug resistance-associated protein 2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
7.6.2.3 physiological function apical multidrug resistance-associated protein 2 plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites Homo sapiens
7.6.2.3 physiological function apical multidrug resistance-associated protein 2 plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites Rattus norvegicus
7.6.2.3 physiological function the enzyme plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites Mus musculus
7.6.2.3 physiological function the enzyme plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites Homo sapiens
7.6.2.3 physiological function the enzyme plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites Rattus norvegicus