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Literature summary extracted from

  • Sanllehi, P.; Abad, J.L.; Bujons, J.; Casas, J.; Delgado, A.
    Studies on the inhibition of sphingosine-1-phosphate lyase by stabilized reaction intermediates and stereodefined azido phosphates (2016), Eur. J. Med. Chem., 123, 905-915 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.2.27 (2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
-
 Homo sapiens
4.1.2.27 (2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
-
 Symbiobacterium thermophilum
4.1.2.27 (2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Homo sapiens
4.1.2.27 (2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Symbiobacterium thermophilum
4.1.2.27 (2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
-
 Homo sapiens
4.1.2.27 (2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
-
 Symbiobacterium thermophilum
4.1.2.27 (2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Homo sapiens
4.1.2.27 (2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Symbiobacterium thermophilum
4.1.2.27 (2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
-
 Homo sapiens
4.1.2.27 (2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
-
 Symbiobacterium thermophilum
4.1.2.27 (2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Homo sapiens
4.1.2.27 (2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Symbiobacterium thermophilum
4.1.2.27 (2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
-
 Homo sapiens
4.1.2.27 (2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
-
 Symbiobacterium thermophilum
4.1.2.27 (2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Homo sapiens
4.1.2.27 (2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
-
 Symbiobacterium thermophilum
4.1.2.27 1-deoxysphinganine 1-phosphonate
-
 Homo sapiens
4.1.2.27 1-deoxysphinganine 1-phosphonate
-
 Symbiobacterium thermophilum
4.1.2.27 2-vinyldihydrosphingosine 1-phosphate
-
 Homo sapiens
4.1.2.27 2-vinyldihydrosphingosine 1-phosphate
-
 Symbiobacterium thermophilum
4.1.2.27 4-deoxypyridoxine
-
 Homo sapiens
4.1.2.27 4-deoxypyridoxine
-
 Symbiobacterium thermophilum
4.1.2.27 FTY720
-
 Homo sapiens
4.1.2.27 FTY720
-
 Symbiobacterium thermophilum
4.1.2.27 phosphopyridoxyl sphinganine 1-phosphate
-
 Homo sapiens
4.1.2.27 phosphopyridoxyl sphinganine 1-phosphate
-
 Symbiobacterium thermophilum
4.1.2.27 phosphopyridoxyl sphingosine 1-phosphate
-
 Homo sapiens
4.1.2.27 phosphopyridoxyl sphingosine 1-phosphate
-
 Symbiobacterium thermophilum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.2.27 endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.27 sphinganine 1-phosphate Homo sapiens
-
 phosphoethanolamine + palmitaldehyde
-
 ir
4.1.2.27 sphinganine 1-phosphate Symbiobacterium thermophilum
-
 phosphoethanolamine + palmitaldehyde
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.27 Homo sapiens
-
-
-
4.1.2.27 Symbiobacterium thermophilum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.27 RBM13
-
 Homo sapiens ?
-
 ?
4.1.2.27 RBM13
-
 Symbiobacterium thermophilum ?
-
 ?
4.1.2.27 sphinganine 1-phosphate
-
 Homo sapiens phosphoethanolamine + palmitaldehyde
-
 ir
4.1.2.27 sphinganine 1-phosphate
-
 Symbiobacterium thermophilum phosphoethanolamine + palmitaldehyde
-
 ir

Synonyms

EC Number Synonyms Comment Organism
4.1.2.27 S1PL
-
 Homo sapiens
4.1.2.27 S1PL
-
 Symbiobacterium thermophilum
4.1.2.27 sphingosine-1-phosphate lyase
-
 Homo sapiens
4.1.2.27 sphingosine-1-phosphate lyase
-
 Symbiobacterium thermophilum

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.2.27 pyridoxal 5'-phosphate
-
 Homo sapiens
4.1.2.27 pyridoxal 5'-phosphate
-
 Symbiobacterium thermophilum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.2.27 0.005
-
 1-deoxysphinganine 1-phosphonate at pH 10.6 and 37°C Homo sapiens
4.1.2.27 0.005
-
 1-deoxysphinganine 1-phosphonate at pH 10.6 and 37°C Symbiobacterium thermophilum
4.1.2.27 0.0056
-
 (2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate at pH 10.6 and 37°C Homo sapiens
4.1.2.27 0.0063
-
 (2R,3S)-2-azido-3-hydroxyoctadecyl phosphate at pH 10.6 and 37°C Homo sapiens
4.1.2.27 0.0091
-
 (2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate at pH 10.6 and 37°C Homo sapiens
4.1.2.27 0.0164
-
 (2S,3S)-2-azido-3-hydroxyoctadecyl phosphate at pH 10.6 and 37°C Homo sapiens
4.1.2.27 0.0175
-
 (2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate at pH 10.6 and 37°C Homo sapiens
4.1.2.27 0.019
-
 (2S,3R)-2-azido-3-hydroxyoctadecyl phosphate at pH 10.6 and 37°C Homo sapiens
4.1.2.27 0.0204
-
 (2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate at pH 10.6 and 37°C Homo sapiens
4.1.2.27 0.0367
-
 (2R,3R)-2-azido-3-hydroxyoctadecyl phosphate at pH 10.6 and 37°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.1.2.27 0.0024
-
 at pH 10.6 and 37°C Homo sapiens 2-vinyldihydrosphingosine 1-phosphate
4.1.2.27 0.0024
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum 2-vinyldihydrosphingosine 1-phosphate
4.1.2.27 0.0052
-
 at pH 10.6 and 37°C Homo sapiens (2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
4.1.2.27 0.0101
-
 at pH 10.6 and 37°C Homo sapiens (2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
4.1.2.27 0.0108
-
 at pH 10.6 and 37°C Homo sapiens (2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
4.1.2.27 0.0117
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
4.1.2.27 0.0129
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2S,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
4.1.2.27 0.0138
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2R,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
4.1.2.27 0.016
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
4.1.2.27 0.0218
-
 at pH 10.6 and 37°C Homo sapiens (2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
4.1.2.27 0.0229
-
 at pH 10.6 and 37°C Homo sapiens (2R,3R,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
4.1.2.27 0.0243
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
4.1.2.27 0.025
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2R,3S)-2-azido-3-hydroxyoctadecyl phosphate
4.1.2.27 0.0257
-
 at pH 10.6 and 37°C Homo sapiens (2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
4.1.2.27 0.0257
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2S,3R)-2-azido-3-hydroxyoctadecyl phosphate
4.1.2.27 0.0272
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum (2S,3S)-2-azido-3-hydroxyoctadecyl phosphate
4.1.2.27 0.0283
-
 at pH 10.6 and 37°C Homo sapiens (2R,3R)-2-azido-3-hydroxyoctadecyl phosphate
4.1.2.27 0.0288
-
 at pH 10.6 and 37°C Homo sapiens (2S,3S,4E)-2-azido-3-hydroxyoctadec-4-en-1-yl phosphate
4.1.2.27 0.047
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum phosphopyridoxyl sphinganine 1-phosphate
4.1.2.27 0.0524
-
 at pH 10.6 and 37°C Homo sapiens FTY720
4.1.2.27 0.0524
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum FTY720
4.1.2.27 0.0534
-
 at pH 10.6 and 37°C Symbiobacterium thermophilum phosphopyridoxyl sphingosine 1-phosphate
4.1.2.27 0.0811
-
 at pH 10.6 and 37°C Homo sapiens phosphopyridoxyl sphinganine 1-phosphate
4.1.2.27 0.089
-
 at pH 10.6 and 37°C Homo sapiens phosphopyridoxyl sphingosine 1-phosphate