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Literature summary extracted from
- The Krebs cycle enzyme alpha-ketoglutarate decarboxylase is an essential glycosomal protein in bloodstream African trypanosomes (2015), Eukaryot. Cell, 14, 206-215 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.71 | expression in Trypanosoma brucei | Trypanosoma brucei |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.1.1.71 | glycosome | N-terminal 18 amino acids of alpha-KDE1 contain overlapping mitochondrion- and peroxisome-targeting sequences and are sufficient to direct localization to the glycosome | Trypanosoma brucei | 20015 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.71 | Trypanosoma brucei | - |
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General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 4.1.1.71 | physiological function | Despite the lack of a functional Krebs cycle, x02alpha-KDE1 is expressed in bloodstream form of Trypanosoma brucei. RNAi treatment of alpha-KDE1 mRNA results in rapid growth arrest and killing. Cell death is preceded by progressive swelling of the flagellar pocket as a consequence of recruitment of both flagellar and plasma membranes into the pocket | Trypanosoma brucei |
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Release 2023.1 (January 2023)
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