Any feedback?
Literature summary extracted from
- Investigation of potential inhibitors of chorismate-utilizing enzymes (2015), Curr. Med. Chem., 22, 1383-1399 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.2.99.21 | sequence comparisons | Pseudomonas aeruginosa |
| 5.4.4.2 | sequence comparisons | Yersinia pestis |
| 5.4.4.2 | sequence comparisons | Escherichia coli |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.4.4.2 | K190A | inactive mutant | Escherichia coli |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.3.27 | (1R,4R,5S,6S)-4-[(1-carboxyethenyl)oxy]-5-hydroxy-7-oxabicyclo[4.1.0]hept-2-ene-2-carboxylic acid | - |
Serratia marcescens |  |
| 4.1.3.27 | (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | (3R,4R)-3-azido-4-hydroxycyclohexa-1,5-diene-1-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | (3R,4R)-3-[(1-carboxyethenyl)oxy]-4-hydroxy-6-methylidenecyclohex-1-ene-1-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | (3R,4R)-3-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | (3S)-3-[(1-carboxyethenyl)oxy]cyclohepta-1,6-diene-1-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | (4R,5R)-5-(carboxymethoxy)-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | (4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | (4R,5R)-5-[(1R)-1-carboxyethoxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | (4R,5R)-5-[(1S)-1-carboxyethoxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | (4R,5R)-5-[(2-carboxyprop-2-en-1-yl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 1-(1-carboxyethyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 1-(1-carboxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 1-(2-carboxyprop-2-en-1-yl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 1-(2-carboxyprop-2-en-1-yl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 1-(carboxymethyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 2-amino-3-(1-carboxyethoxy)benzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 2-[(1-carboxyethyl)amino]pyridine-4-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 2-[(carboxymethyl)amino]pyridine-4-carboxylic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 2-[[(1R,6R)-3-bromo-6-hydroxycyclohexa-2,4-dien-1-yl]oxy]prop-2-enoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 3-(1-carboxyethoxy)-2-hydroxybenzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 3-(1-carboxyethoxy)-2-nitrobenzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 3-(1-carboxyethoxy)-4,5-dihydroxybenzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 3-(1-carboxyethoxy)-4-(hydroxymethyl)benzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 3-(1-carboxyethoxy)-4-(sulfanylmethyl)benzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 3-(1-carboxyethoxy)-4-hydroxybenzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 3-(1-carboxyethoxy)-4-methoxybenzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 3-(1-carboxyethoxy)-4-methylbenzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 3-(1-carboxyethoxy)benzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 3-[(1-carboxyethenyl)oxy]-4,5-dihydroxybenzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 3-[(2-carboxyprop-2-en-1-yl)oxy]-4,5-dihydroxybenzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 4-(azidomethyl)-3-(1-carboxyethoxy)benzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 4-amino-3-(1-carboxyethoxy)benzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | 4-amino-3-[(1-carboxyethyl)amino]benzoic acid | - |
Serratia marcescens | |
| 4.1.3.27 | [(3R,4R)-3-[(1-carboxyethenyl)oxy]-4-hydroxycyclohexa-1,5-dien-1-yl]phosphonate | - |
Serratia marcescens | |
| 4.1.3.27 | [4-carboxy-2-(1-carboxyethoxy)phenyl]methanaminium | - |
Serratia marcescens | |
| 4.2.99.21 | (4R,5R)-5-(carboxymethoxy)-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | (4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | (4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | inhibition of salicylate synthase activity | Pseudomonas aeruginosa | |
| 4.2.99.21 | (4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | (4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Yersinia pestis | |
| 4.2.99.21 | (4R,5R)-5-[(1R)-1-carboxyethoxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | (4R,5R)-5-[(1S)-1-carboxyethoxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | (4R,5R)-5-[(2-carboxyprop-2-en-1-yl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 1-(2-sulfanylidene-2,3-dihydro-1H-benzimidazol-1-yl)ethan-1-one | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 2-amino-3-(1-carboxyethoxy)benzoic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 3-(1-carboxyethoxy)-2-hydroxybenzoic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 3-(1-carboxyethoxy)-2-nitrobenzoic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 3-(1-carboxyethoxy)-4,5-dihydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-(1-carboxyethoxy)-4-(hydroxymethyl)benzoic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 3-(1-carboxyethoxy)-4-(sulfanylmethyl)benzoic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 3-(1-carboxyethoxy)-4-hydroxybenzoic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 3-(1-carboxyethoxy)-4-methoxybenzoic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 3-(1-carboxyethoxy)-4-methylbenzoic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 3-(1-carboxyethoxy)benzoic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 3-(3,4-dichlorobenzene-1-sulfonyl)benzene-1-sulfonamide | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-([(E)-1-carboxy-2-[2-(trifluoromethyl)phenyl]ethenyl]oxy)-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-([(E)-1-carboxy-2-[3-(trifluoromethyl)phenyl]ethenyl]oxy)-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-([(E)-1-carboxy-2-[4-(trifluoromethyl)phenyl]ethenyl]oxy)-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-([(E)-2-[2-(acetyloxy)phenyl]-1-carboxyethenyl]oxy)-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-([(E)-2-[3-(acetyloxy)phenyl]-1-carboxyethenyl]oxy)-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-([(E)-2-[4-(acetyloxy)phenyl]-1-carboxyethenyl]oxy)-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[(1-carboxyethenyl)oxy]-4,5-dihydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[(1-carboxyethenyl)oxy]-4-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[(1-carboxyethenyl)oxy]benzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[(2-carboxyprop-2-en-1-yl)oxy]-4,5-dihydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(1E)-1-carboxy-3-methylbut-1-en-1-yl]oxy]-4-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(1E)-1-carboxy-3-methylbut-1-en-1-yl]oxy]benzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(1E)-1-carboxybut-1-en-1-yl]oxy]benzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(1E)-1-carboxyprop-1-en-1-yl]oxy]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(1E)-1-carboxyprop-1-en-1-yl]oxy]-4-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(1E)-1-carboxyprop-1-en-1-yl]oxy]benzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(E)-1-carboxy-2-(2-chlorophenyl)ethenyl]oxy]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(E)-1-carboxy-2-(2-methylphenyl)ethenyl]oxy]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(E)-1-carboxy-2-(3-chlorophenyl)ethenyl]oxy]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(E)-1-carboxy-2-(3-methylphenyl)ethenyl]oxy]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(E)-1-carboxy-2-(4-chlorophenyl)ethenyl]oxy]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(E)-1-carboxy-2-(4-methylphenyl)ethenyl]oxy]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(E)-1-carboxy-2-phenylethenyl]oxy]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(E)-1-carboxy-2-phenylethenyl]oxy]-4-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(E)-1-carboxy-2-phenylethenyl]oxy]benzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(E)-2-(2-bromophenyl)-1-carboxyethenyl]oxy]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(E)-2-(3-bromophenyl)-1-carboxyethenyl]oxy]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 3-[[(E)-2-(4-bromophenyl)-1-carboxyethenyl]oxy]-2-hydroxybenzoic acid | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | 4,4'-sulfonylbis(2,6-dinitrophenol) | - |
Pseudomonas aeruginosa | |
| 4.2.99.21 | 4,4'-sulfonylbis(2,6-dinitrophenol) | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 4,6-dinitro-2-oxo-1,3-benzoxathiol-5-yl methyl carbonate | - |
Pseudomonas aeruginosa | |
| 4.2.99.21 | 4,6-dinitro-2-oxo-2H-1,3-benzoxathiol-5-yl methyl carbonate | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 4-(azidomethyl)-3-(1-carboxyethoxy)benzoic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 4-amino-3-(1-carboxyethoxy)benzoic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | 5-[(2-carboxyphenyl)sulfamoyl]-2-hydroxybenzoic acid | - |
Pseudomonas aeruginosa | |
| 4.2.99.21 | 5-[(2-carboxyphenyl)sulfamoyl]-2-methylbenzoic acid | - |
Yersinia enterocolitica | |
| 4.2.99.21 | methyl 2-hydroxy-3-([(1E)-3-methoxy-3-oxo-1-[2-(trifluoromethyl)phenyl]prop-1-en-2-yl]oxy)benzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 2-hydroxy-3-([(1E)-3-methoxy-3-oxo-1-[3-(trifluoromethyl)phenyl]prop-1-en-2-yl]oxy)benzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 2-hydroxy-3-([(1E)-3-methoxy-3-oxo-1-[4-(trifluoromethyl)phenyl]prop-1-en-2-yl]oxy)benzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 2-hydroxy-3-[[(1E)-3-methoxy-1-(2-methylphenyl)-3-oxoprop-1-en-2-yl]oxy]benzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 2-hydroxy-3-[[(1E)-3-methoxy-1-(3-methylphenyl)-3-oxoprop-1-en-2-yl]oxy]benzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 2-hydroxy-3-[[(1E)-3-methoxy-1-(4-methylphenyl)-3-oxoprop-1-en-2-yl]oxy]benzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 3-([(1E)-1-[2-(acetyloxy)phenyl]-3-methoxy-3-oxoprop-1-en-2-yl]oxy)-2-hydroxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 3-([(1E)-1-[3-(acetyloxy)phenyl]-3-methoxy-3-oxoprop-1-en-2-yl]oxy)-2-hydroxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 3-([(1E)-1-[4-(acetyloxy)phenyl]-3-methoxy-3-oxoprop-1-en-2-yl]oxy)-2-hydroxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 3-[[(1E)-1-(2-bromophenyl)-3-methoxy-3-oxoprop-1-en-2-yl]oxy]-2-hydroxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 3-[[(1E)-1-(2-chlorophenyl)-3-methoxy-3-oxoprop-1-en-2-yl]oxy]-2-hydroxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 3-[[(1E)-1-(3-bromophenyl)-3-methoxy-3-oxoprop-1-en-2-yl]oxy]-2-hydroxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 3-[[(1E)-1-(3-chlorophenyl)-3-methoxy-3-oxoprop-1-en-2-yl]oxy]-2-hydroxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 3-[[(1E)-1-(4-bromophenyl)-3-methoxy-3-oxoprop-1-en-2-yl]oxy]-2-hydroxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | methyl 3-[[(1E)-1-(4-chlorophenyl)-3-methoxy-3-oxoprop-1-en-2-yl]oxy]-2-hydroxybenzoate | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | additional information | inhibitor structure-function realtionship and molecular docking; inhibitor structure-function relationship and molecular docking | Mycobacterium tuberculosis | |
| 4.2.99.21 | additional information | inhibitor structure-function realtionship and molecular docking; inhibitor structure-function relationship and molecular docking | Yersinia enterocolitica | |
| 4.2.99.21 | additional information | inhibitor structure-function realtionship and molecular docking; inhibitor structure-function relationship and molecular docking | Yersinia pestis | |
| 4.2.99.21 | N-ethyl-3-(3-oxo-1,2-benzothiazol-2(3H)-yl)benzene-1-sulfonamide | - |
Mycobacterium tuberculosis | |
| 4.2.99.21 | [4-carboxy-2-(1-carboxyethoxy)phenyl]methanaminium | - |
Yersinia enterocolitica | |
| 5.4.4.2 | (4R,5R)-5-(carboxymethoxy)-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Escherichia coli | |
| 5.4.4.2 | (4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | inhibition of isochorismate synthase activity and salicylate synthase activity | Escherichia coli | |
| 5.4.4.2 | (4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
| 5.4.4.2 | (4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Pseudomonas aeruginosa | |
| 5.4.4.2 | (4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Yersinia enterocolitica | |
| 5.4.4.2 | (4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Yersinia pestis | |
| 5.4.4.2 | (4R,5R)-5-[(1R)-1-carboxyethoxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Escherichia coli | |
| 5.4.4.2 | (4R,5R)-5-[(1S)-1-carboxyethoxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Escherichia coli | |
| 5.4.4.2 | (4R,5R)-5-[(2-carboxyprop-2-en-1-yl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Escherichia coli | |
| 5.4.4.2 | (4R,5R,6S)-6-amino-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Escherichia coli | |
| 5.4.4.2 | (4R,5R,6S)-6-amino-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Pseudomonas aeruginosa | |
| 5.4.4.2 | (4R,5S,6S)-4-amino-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Escherichia coli | |
| 5.4.4.2 | (4R,5S,6S)-4-amino-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohex-1-ene-1-carboxylic acid | - |
Pseudomonas aeruginosa | |
| 5.4.4.2 | (4R,5S,6S)-5-[(1-carboxyethenyl)oxy]-4,6-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Escherichia coli | |
| 5.4.4.2 | (4R,5S,6S)-5-[(1-carboxyethenyl)oxy]-4,6-dihydroxycyclohex-1-ene-1-carboxylic acid | - |
Pseudomonas aeruginosa | |
| 5.4.4.2 | additional information | inhibitor structure-function relationship and molecular docking | Escherichia coli | |
| 5.4.4.2 | additional information | inhibitor structure-function realtionship and molecular docking | Mycobacterium tuberculosis | |
| 5.4.4.2 | additional information | inhibitor structure-function relationship and molecular docking | Pseudomonas aeruginosa | |
| 5.4.4.2 | additional information | inhibitor structure-function relationship and molecular docking | Yersinia enterocolitica | |
| 5.4.4.2 | additional information | inhibitor structure-function relationship and molecular docking | Yersinia pestis |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.3.27 | Mg2+ | required for activity | Serratia marcescens | |
| 4.2.99.21 | Mg2+ | required | Yersinia pestis | |
| 4.2.99.21 | Mg2+ | required | Yersinia enterocolitica | |
| 4.2.99.21 | Mg2+ | required | Pseudomonas aeruginosa | |
| 4.2.99.21 | Mg2+ | required | Mycobacterium tuberculosis | |
| 5.4.4.2 | Mg2+ | required | Yersinia pestis | |
| 5.4.4.2 | Mg2+ | required | Yersinia enterocolitica | |
| 5.4.4.2 | Mg2+ | required | Mycobacterium tuberculosis | |
| 5.4.4.2 | Mg2+ | strongly dependent on, magnesium ions interact with chorismate in the active site, forming a magnesium-coordinated transition state during the reaction | Escherichia coli | |
| 5.4.4.2 | Mg2+ | strongly dependent on, magnesium ions interact with chorismate in the active site, forming a magnesium-coordinated transition state during the reaction | Pseudomonas aeruginosa | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.3.27 | chorismate + L-glutamine | Serratia marcescens | one subunit of the enzyme contains a chorismate binding site and catalyzes the formation of anthranilate via 2-amino-2-deoxyisochorismate. After the first step, the intermediate remains bound to the enzyme, where it is subsequently converted to anthranilate through the elimination of pyruvate | anthranilate + pyruvate + L-glutamate | - |
? | |
| 4.2.99.21 | isochorismate | Yersinia pestis | - |
salicylate + pyruvate | - |
? | |
| 4.2.99.21 | isochorismate | Yersinia enterocolitica | - |
salicylate + pyruvate | - |
? | |
| 4.2.99.21 | isochorismate | Pseudomonas aeruginosa | - |
salicylate + pyruvate | - |
? | |
| 4.2.99.21 | isochorismate | Mycobacterium tuberculosis | - |
salicylate + pyruvate | - |
? | |
| 4.2.99.21 | isochorismate | Mycobacterium tuberculosis ATCC 25618 | - |
salicylate + pyruvate | - |
? | |
| 4.2.99.21 | isochorismate | Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1 | - |
salicylate + pyruvate | - |
? | |
| 5.4.4.2 | Chorismate | Yersinia pestis | - |
Isochorismate | - |
r | |
| 5.4.4.2 | Chorismate | Yersinia enterocolitica | - |
Isochorismate | - |
r | |
| 5.4.4.2 | Chorismate | Mycobacterium tuberculosis | - |
Isochorismate | - |
r | |
| 5.4.4.2 | Chorismate | Mycobacterium tuberculosis ATCC 25618 | - |
Isochorismate | - |
r | |
| 5.4.4.2 | isochorismate | Escherichia coli | - |
chorismate | - |
r | |
| 5.4.4.2 | isochorismate | Pseudomonas aeruginosa | - |
chorismate | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.3.27 | Serratia marcescens | - |
- |
- |
| 4.2.99.21 | Mycobacterium tuberculosis | P9WFX1 | - |
- |
| 4.2.99.21 | Mycobacterium tuberculosis ATCC 25618 | P9WFX1 | - |
- |
| 4.2.99.21 | no activity in Homo sapiens | - |
- |
- |
| 4.2.99.21 | Pseudomonas aeruginosa | Q51507 | - |
- |
| 4.2.99.21 | Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1 | Q51507 | - |
- |
| 4.2.99.21 | Yersinia enterocolitica | - |
- |
- |
| 4.2.99.21 | Yersinia pestis | - |
- |
- |
| 5.4.4.2 | Escherichia coli | P38051 | - |
- |
| 5.4.4.2 | Mycobacterium tuberculosis | P9WFX1 | - |
- |
| 5.4.4.2 | no activity in Homo sapiens | - |
- |
- |
| 5.4.4.2 | Pseudomonas aeruginosa | Q51508 | - |
- |
| 5.4.4.2 | Yersinia enterocolitica | - |
- |
- |
| 5.4.4.2 | Yersinia pestis | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 4.2.99.21 | isochorismate = salicylate + pyruvate | overall reaction, salicylate sythase converts chorismate into salicylate via an isochorismate intermediate | Yersinia pestis | |
| 4.2.99.21 | isochorismate = salicylate + pyruvate | overall reaction, salicylate sythase converts chorismate into salicylate via an isochorismate intermediate | Yersinia enterocolitica | |
| 4.2.99.21 | isochorismate = salicylate + pyruvate | overall reaction, salicylate sythase converts chorismate into salicylate via an isochorismate intermediate | Mycobacterium tuberculosis | |
| 5.4.4.2 | chorismate = isochorismate | isochorismate synthase (IS) performs a 1,5-displacement mechanism during the chorismate conversion to intermediates through the use of a nucleophile, which is water in the case of IS, but might also be possible with ammonia. The hydroxyl group in the isochorismate is generated from water and not through an intramolecular rearrangement | Escherichia coli | |
| 5.4.4.2 | chorismate = isochorismate | isochorismate synthase performs a 1,5-displacement mechanism during the chorismate conversion to intermediates through the use of a nucleophile, which is water in the case of isochorismate synthase, but might also be possible with ammonia. The hydroxyl group in the isochorismate is generated from water and not through an intramolecular rearrangement | Pseudomonas aeruginosa |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.3.27 | chorismate + L-glutamine | one subunit of the enzyme contains a chorismate binding site and catalyzes the formation of anthranilate via 2-amino-2-deoxyisochorismate. After the first step, the intermediate remains bound to the enzyme, where it is subsequently converted to anthranilate through the elimination of pyruvate | Serratia marcescens | anthranilate + pyruvate + L-glutamate | - |
? | |
| 4.2.99.21 | isochorismate | - |
Yersinia pestis | salicylate + pyruvate | - |
? | |
| 4.2.99.21 | isochorismate | - |
Yersinia enterocolitica | salicylate + pyruvate | - |
? | |
| 4.2.99.21 | isochorismate | - |
Pseudomonas aeruginosa | salicylate + pyruvate | - |
? | |
| 4.2.99.21 | isochorismate | - |
Mycobacterium tuberculosis | salicylate + pyruvate | - |
? | |
| 4.2.99.21 | isochorismate | - |
Mycobacterium tuberculosis ATCC 25618 | salicylate + pyruvate | - |
? | |
| 4.2.99.21 | isochorismate | - |
Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1 | salicylate + pyruvate | - |
? | |
| 4.2.99.21 | additional information | the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Yersinia pestis | ? | - |
? | |
| 4.2.99.21 | additional information | the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Yersinia enterocolitica | ? | - |
? | |
| 4.2.99.21 | additional information | the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Mycobacterium tuberculosis | ? | - |
? | |
| 4.2.99.21 | additional information | the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Mycobacterium tuberculosis ATCC 25618 | ? | - |
? | |
| 5.4.4.2 | Chorismate | - |
Yersinia pestis | Isochorismate | - |
r | |
| 5.4.4.2 | Chorismate | - |
Yersinia enterocolitica | Isochorismate | - |
r | |
| 5.4.4.2 | Chorismate | - |
Mycobacterium tuberculosis | Isochorismate | - |
r | |
| 5.4.4.2 | Chorismate | - |
Mycobacterium tuberculosis ATCC 25618 | Isochorismate | - |
r | |
| 5.4.4.2 | isochorismate | - |
Escherichia coli | chorismate | - |
r | |
| 5.4.4.2 | isochorismate | - |
Pseudomonas aeruginosa | chorismate | - |
r | |
| 5.4.4.2 | additional information | the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Yersinia pestis | ? | - |
? | |
| 5.4.4.2 | additional information | the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Yersinia enterocolitica | ? | - |
? | |
| 5.4.4.2 | additional information | the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Mycobacterium tuberculosis | ? | - |
? | |
| 5.4.4.2 | additional information | the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Mycobacterium tuberculosis ATCC 25618 | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.4.4.2 | monomer | - |
Escherichia coli |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.99.21 | IPL | UniProt | Pseudomonas aeruginosa |
| 4.2.99.21 | isochorismate-pyruvate lyase | - |
Pseudomonas aeruginosa |
| 4.2.99.21 | PchB | - |
Pseudomonas aeruginosa |
| 4.2.99.21 | salicylate synthase | EC 5.4.4.2 and 4.2.99.21 | Yersinia pestis |
| 4.2.99.21 | salicylate synthase | EC 5.4.4.2 and 4.2.99.21 | Yersinia enterocolitica |
| 4.2.99.21 | salicylate synthase | EC 5.4.4.2 and 4.2.99.21 | Mycobacterium tuberculosis |
| 5.4.4.2 | MenF | - |
Escherichia coli |
| 5.4.4.2 | PchA | - |
Pseudomonas aeruginosa |
| 5.4.4.2 | salicylate biosynthesis isochorismate synthase | UniProt | Pseudomonas aeruginosa |
| 5.4.4.2 | salicylate synthase | EC 5.4.4.2 and 4.2.99.21 | Yersinia pestis |
| 5.4.4.2 | salicylate synthase | EC 5.4.4.2 and 4.2.99.21 | Yersinia enterocolitica |
| 5.4.4.2 | salicylate synthase | EC 5.4.4.2 and 4.2.99.21 | Mycobacterium tuberculosis |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.3.27 | 0.028 | - |
3-(1-carboxyethoxy)-4,5-dihydroxybenzoic acid | pH and temperature not specified in the publication | Serratia marcescens | |
| 4.1.3.27 | 0.03 | - |
3-(1-carboxyethoxy)-4-hydroxybenzoic acid | pH and temperature not specified in the publication | Serratia marcescens | |
| 4.1.3.27 | 0.03 | - |
(3S)-3-[(1-carboxyethenyl)oxy]cyclohepta-1,6-diene-1-carboxylic acid | pH and temperature not specified in the publication | Serratia marcescens | |
| 4.1.3.27 | 0.09 | - |
3-[(2-carboxyprop-2-en-1-yl)oxy]-4,5-dihydroxybenzoic acid | pH and temperature not specified in the publication | Serratia marcescens | |
| 4.1.3.27 | 0.23 | - |
3-[(1-carboxyethenyl)oxy]-4,5-dihydroxybenzoic acid | pH and temperature not specified in the publication | Serratia marcescens | |
| 4.1.3.27 | 0.29 | - |
(4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | pH and temperature not specified in the publication | Serratia marcescens | |
| 4.2.99.21 | 0.0001 | - |
4,4'-sulfonylbis(2,6-dinitrophenol) | pH and temperature not specified in the publication | Pseudomonas aeruginosa | |
| 4.2.99.21 | 0.0001 | - |
5-[(2-carboxyphenyl)sulfamoyl]-2-hydroxybenzoic acid | pH and temperature not specified in the publication | Pseudomonas aeruginosa | |
| 4.2.99.21 | 0.00087 | - |
4,6-dinitro-2-oxo-1,3-benzoxathiol-5-yl methyl carbonate | pH and temperature not specified in the publication | Pseudomonas aeruginosa | |
| 4.2.99.21 | 0.025 | - |
4,6-dinitro-2-oxo-2H-1,3-benzoxathiol-5-yl methyl carbonate | pH and temperature not specified in the publication | Yersinia enterocolitica | |
| 4.2.99.21 | 0.16 | - |
(4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | pH and temperature not specified in the publication | Yersinia enterocolitica | |
| 4.2.99.21 | 0.16 | - |
(4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | pH and temperature not specified in the publication, inhibition of salicylate synthase activity | Pseudomonas aeruginosa | |
| 4.2.99.21 | 1.4 | - |
3-(1-carboxyethoxy)-4,5-dihydroxybenzoic acid | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 4.2.99.21 | 1.7 | - |
3-[(1-carboxyethenyl)oxy]-4,5-dihydroxybenzoic acid | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 4.2.99.21 | 3 | - |
3-[(2-carboxyprop-2-en-1-yl)oxy]-4,5-dihydroxybenzoic acid | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 5.4.4.2 | 0.000053 | - |
(4R,5R,6S)-6-amino-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | pH and temperature not specified in the publication | Escherichia coli | |
| 5.4.4.2 | 0.00036 | - |
(4R,5S,6S)-5-[(1-carboxyethenyl)oxy]-4,6-dihydroxycyclohex-1-ene-1-carboxylic acid | pH and temperature not specified in the publication | Escherichia coli | |
| 5.4.4.2 | 0.00046 | - |
(4R,5S,6S)-4-amino-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohex-1-ene-1-carboxylic acid | pH and temperature not specified in the publication | Escherichia coli | |
| 5.4.4.2 | 0.03 | - |
(4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | pH and temperature not specified in the publication, inhibition of isochorismate synthase activity | Escherichia coli | |
| 5.4.4.2 | 0.16 | - |
(4R,5R)-5-[(1-carboxyethenyl)oxy]-4-hydroxycyclohex-1-ene-1-carboxylic acid | pH and temperature not specified in the publication, inhibition of salicylate synthase activity | Escherichia coli | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 4.2.99.21 | metabolism | the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). Salicylate synthase converts chorismate into salicylate through a two-step reaction | Pseudomonas aeruginosa |
| 4.2.99.21 | metabolism | the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Yersinia pestis |
| 4.2.99.21 | metabolism | the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Yersinia enterocolitica |
| 4.2.99.21 | metabolism | the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Mycobacterium tuberculosis |
| 4.2.99.21 | physiological function | the enzyme is involved in the biosynthesis of pyochelin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria | Pseudomonas aeruginosa |
| 4.2.99.21 | physiological function | the enzyme is involved in the biosynthesis of the siderophore mycobactin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria | Mycobacterium tuberculosis |
| 4.2.99.21 | physiological function | the enzyme is involved in the biosynthesis of the siderophore yersiniabactin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria | Yersinia pestis |
| 4.2.99.21 | physiological function | the enzyme is involved in the biosynthesis of the siderophore yersiniabactin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria | Yersinia enterocolitica |
| 5.4.4.2 | metabolism | the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). Salicylate synthase converts chorismate into salicylate through a two-step reaction | Escherichia coli |
| 5.4.4.2 | metabolism | the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). Salicylate synthase converts chorismate into salicylate through a two-step reaction | Pseudomonas aeruginosa |
| 5.4.4.2 | metabolism | the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Yersinia pestis |
| 5.4.4.2 | metabolism | the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Yersinia enterocolitica |
| 5.4.4.2 | metabolism | the first committed step during the biosynthesis of siderophores, which are small molecules capable of chelating iron from the host organism, is the conversion of chorismate into isochorismate by isochorismate synthase (EC 5.4.4.2) and consequently to salicylate by isochorismate pyruvate-lyase (EC 4.2.99.21). the bifunctional salicylate synthase converts chorismate into salicylate through a two-step reaction, exhibiting both isochorismate synthase (EC 5.4.4.2) and isochorismate lyase (EC 4.2.99.21) activities | Mycobacterium tuberculosis |
| 5.4.4.2 | additional information | enzyme three-dimensional structure analysis, the lysine residue, Lys190, might be involved in the activation of water molecules and the subsequent nucleophilic attack on the C2 carbon of chorismate without directly involving the magnesium ion, participation of the Lys residue during the activation of the substrate or nucleophilic agent | Escherichia coli |
| 5.4.4.2 | additional information | enzyme three-dimensional structure analysis, the lysine residue, Lys190, might be involved in the activation of water molecules and the subsequent nucleophilic attack on the C2 carbon of chorismate without directly involving the magnesium ion, participation of the Lys residue during the activation of the substrate or nucleophilic agent | Pseudomonas aeruginosa |
| 5.4.4.2 | physiological function | chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria | Escherichia coli |
| 5.4.4.2 | physiological function | the enzyme is involved in the biosynthesis of pyochelin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria | Pseudomonas aeruginosa |
| 5.4.4.2 | physiological function | the enzyme is involved in the biosynthesis of the siderophore mycobactin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria | Mycobacterium tuberculosis |
| 5.4.4.2 | physiological function | the enzyme is involved in the biosynthesis of the siderophore yersiniabactin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria | Yersinia pestis |
| 5.4.4.2 | physiological function | the enzyme is involved in the biosynthesis of the siderophore yersiniabactin. Chorismate-utilizing enzymes (CUE) such as chorismate mutase, anthranilate synthase, chorismate pyruvate-lyase, 4-amino-4-deoxychorismate synthase, isochorismate synthase and salicylate synthase are responsible for converting chorismate into various products necessary for the survival of bacteria | Yersinia enterocolitica |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
