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Literature summary extracted from

  • Liu, X.; Xu, J.; Wang, J.; Ji, F.; Yin, X.; Shi, J.
    Involvement of threonine deaminase FgIlv1 in isoleucine biosynthesis and full virulence in Fusarium graminearum (2015), Curr. Genet., 61, 55-65 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.19 L-threonine Fusarium graminearum the enzyme catalyzes the first step in the biosynthesis pathway of isoleucine for conversion of threonine to 2-oxobutanoate 2-oxobutanoate + NH3
-
 ?
4.3.1.19 L-threonine Fusarium graminearum PH-1 the enzyme catalyzes the first step in the biosynthesis pathway of isoleucine for conversion of threonine to 2-oxobutanoate 2-oxobutanoate + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.19 Fusarium graminearum V6QU65
-
-
4.3.1.19 Fusarium graminearum PH-1 V6QU65
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.19 L-threonine
-
 Fusarium graminearum 2-oxobutanoate + NH3
-
 ?
4.3.1.19 L-threonine the enzyme catalyzes the first step in the biosynthesis pathway of isoleucine for conversion of threonine to 2-oxobutanoate Fusarium graminearum 2-oxobutanoate + NH3
-
 ?
4.3.1.19 L-threonine
-
 Fusarium graminearum PH-1 2-oxobutanoate + NH3
-
 ?
4.3.1.19 L-threonine the enzyme catalyzes the first step in the biosynthesis pathway of isoleucine for conversion of threonine to 2-oxobutanoate Fusarium graminearum PH-1 2-oxobutanoate + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.3.1.19 FgIlv1
-
 Fusarium graminearum
4.3.1.19 Threonine deaminase
-
 Fusarium graminearum

General Information

EC Number General Information Comment Organism
4.3.1.19 malfunction the FgILV1 deletion mutant DELTAFgIlv1-3 is unable to grow on minimal medium or fructose gelatin agar which lacks isoleucine. The mutant displays decreased virulence on wheat heads and a low level of deoxynivalenol production in wheat kernels. Deletion of FgILV1 also causes defects in conidial formation and germination Fusarium graminearum
4.3.1.19 metabolism the enzyme catalyzes the first step in the biosynthesis pathway of isoleucine for conversion of threonine to 2-oxobutanoate. FgIlv1 is an essential component in isoleucine biosynthesis and is required for various cellular processes including mycelial and conidial morphogenesis, deoxynivalenol biosynthesis, and full virulence in Fusarium graminearum Fusarium graminearum