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Literature summary extracted from

  • Ballatori, N.; Hammond, C.; Cunningham, J.
    MRP2-mediated reduced glutathione transport in protection against oxidant stress (2003), Comment. Toxicol., 9, 215-228 .
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.3 glutathione
-
Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.3 2-mercaptoethanol
-
Rattus norvegicus
7.6.2.3 dithioerythritol
-
Rattus norvegicus
7.6.2.3 dithiothreitol noncompetitive inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.3 canicular membrane
-
Rattus norvegicus
-
-
7.6.2.3 plasma membrane
-
Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.3 ATP + H2O + glutathione disulfide[side 1] Rattus norvegicus
-
ADP + phosphate + glutathione disulfide[side 2]
-
?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1] Rattus norvegicus
-
ADP + phosphate + glutathione-S-conjugate[side 2]
-
?
7.6.2.3 ATP + H2O + reduced glutathione[side 1] Rattus norvegicus
-
ADP + phosphate + reduced glutathione[side 2]
-
?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.3 Rattus norvegicus Q63120
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.3 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.3 ATP + H2O + glutathione disulfide[side 1]
-
Rattus norvegicus ADP + phosphate + glutathione disulfide[side 2]
-
?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1]
-
Rattus norvegicus ADP + phosphate + glutathione-S-conjugate[side 2]
-
?
7.6.2.3 ATP + H2O + reduced glutathione[side 1]
-
Rattus norvegicus ADP + phosphate + reduced glutathione[side 2]
-
?
7.6.2.3 ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
-
Rattus norvegicus ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
-
?
7.6.2.3 ATP + H2O + S-(aflatoxin B1)glutathione[side 1]
-
Rattus norvegicus ADP + phosphate + S-(aflatoxin B1)glutathione[side 2]
-
?
7.6.2.3 ATP + H2O + S-(vincristinyl)glutathione[side 1]
-
Rattus norvegicus ADP + phosphate + S-(vincristinyl)glutathione[side 2]
-
?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.3 ATP-driven GSH transporter
-
Rattus norvegicus
7.6.2.3 MRP2
-
Rattus norvegicus
7.6.2.3 multidrug resistance-associated protein 2
-
Rattus norvegicus

General Information

EC Number General Information Comment Organism
7.6.2.3 malfunction MRP2-deficient rats are unable to transport reduced glutathione into bile Rattus norvegicus
7.6.2.3 physiological function the enzyme contributes directly to the regulation of the cellular thiol-redox status and therefore to the protection against oxidative stress Rattus norvegicus