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Literature summary extracted from

  • Hiseni, A.; Arends, I.; Otten, L.
    New cofactor-independent hydration biocatalysts Structural, biochemical, and biocatalytic characteristics of carotenoid and oleate hydratases (2015), ChemCatChem, 7, 29-37 .
No PubMed abstract available

Application

EC Number Application Comment Organism
4.2.1.53 synthesis (R)-10-hydroxyoctadecanoic acid, produced by the oleate hydratase is a precursor for gamma-dodecalactone which is an important fragrance and flavour compound Lactobacillus acidophilus
4.2.1.53 synthesis (R)-10-hydroxyoctadecanoic acid, produced by the oleate hydratase is a precursor for gamma-dodecalactone which is an important fragrance and flavour compound Stenotrophomonas maltophilia
4.2.1.53 synthesis (R)-10-hydroxyoctadecanoic acid, produced by the oleate hydratase is a precursor for gamma-dodecalactone which is an important fragrance and flavour compound Elizabethkingia meningoseptica
4.2.1.53 synthesis (R)-10-hydroxyoctadecanoic acid, produced by the oleate hydratase is a precursor for gamma-dodecalactone which is an important fragrance and flavour compound Macrococcus caseolyticus
4.2.1.53 synthesis (R)-10-hydroxyoctadecanoic acid, produced by the oleate hydratase is a precursor for gamma-dodecalactone which is an important fragrance and flavour compound Streptococcus pyogenes
4.2.1.53 synthesis (R)-10-hydroxyoctadecanoic acid, produced by the oleate hydratase is a precursor for gamma-dodecalactone which is an important fragrance and flavour compound Lysinibacillus fusiformis
4.2.1.53 synthesis (R)-10-hydroxyoctadecanoic acid, produced by the oleate hydratase is a precursor for gamma-dodecalactone which is an important fragrance and flavour compound Lacticaseibacillus rhamnosus
4.2.1.53 synthesis (R)-10-hydroxyoctadecanoic acid, produced by the oleate hydratase is a precursor for gamma-dodecalactone which is an important fragrance and flavour compound Lactiplantibacillus plantarum
4.2.1.53 synthesis (R)-10-hydroxyoctadecanoic acid, produced by the oleate hydratase is a precursor for gamma-dodecalactone which is an important fragrance and flavour compound Bifidobacterium breve
4.2.1.53 synthesis (R)-10-hydroxyoctadecanoic acid, produced by the oleate hydratase is a precursor for gamma-dodecalactone which is an important fragrance and flavour compound Bifidobacterium animalis subsp. lactis
4.2.1.53 synthesis one of the largest bottlenecks in producing lactones is the hydroxylation of the fatty acids. The exploitation of oleate hydratase to hydrate oleic acid, which can easily be turned into gamma-dodecalactone after beta-elimination, is therefore the perfect solution to produce this valuable compound from cheap renewable materials (e.g. vegetable oil). The specificity and enantioselectivity of the enzyme will provide the correct lactone Lactobacillus acidophilus
4.2.1.53 synthesis one of the largest bottlenecks in producing lactones is the hydroxylation of the fatty acids. The exploitation of oleate hydratase to hydrate oleic acid, which can easily be turned into gamma-dodecalactone after beta-elimination, is therefore the perfect solution to produce this valuable compound from cheap renewable materials (e.g. vegetable oil). The specificity and enantioselectivity of the enzyme will provide the correct lactone Stenotrophomonas maltophilia
4.2.1.53 synthesis one of the largest bottlenecks in producing lactones is the hydroxylation of the fatty acids. The exploitation of oleate hydratase to hydrate oleic acid, which can easily be turned into gamma-dodecalactone after beta-elimination, is therefore the perfect solution to produce this valuable compound from cheap renewable materials (e.g. vegetable oil). The specificity and enantioselectivity of the enzyme will provide the correct lactone Elizabethkingia meningoseptica
4.2.1.53 synthesis one of the largest bottlenecks in producing lactones is the hydroxylation of the fatty acids. The exploitation of oleate hydratase to hydrate oleic acid, which can easily be turned into gamma-dodecalactone after beta-elimination, is therefore the perfect solution to produce this valuable compound from cheap renewable materials (e.g. vegetable oil). The specificity and enantioselectivity of the enzyme will provide the correct lactone Macrococcus caseolyticus
4.2.1.53 synthesis one of the largest bottlenecks in producing lactones is the hydroxylation of the fatty acids. The exploitation of oleate hydratase to hydrate oleic acid, which can easily be turned into gamma-dodecalactone after beta-elimination, is therefore the perfect solution to produce this valuable compound from cheap renewable materials (e.g. vegetable oil). The specificity and enantioselectivity of the enzyme will provide the correct lactone Streptococcus pyogenes
4.2.1.53 synthesis one of the largest bottlenecks in producing lactones is the hydroxylation of the fatty acids. The exploitation of oleate hydratase to hydrate oleic acid, which can easily be turned into gamma-dodecalactone after beta-elimination, is therefore the perfect solution to produce this valuable compound from cheap renewable materials (e.g. vegetable oil). The specificity and enantioselectivity of the enzyme will provide the correct lactone Lysinibacillus fusiformis
4.2.1.53 synthesis one of the largest bottlenecks in producing lactones is the hydroxylation of the fatty acids. The exploitation of oleate hydratase to hydrate oleic acid, which can easily be turned into gamma-dodecalactone after beta-elimination, is therefore the perfect solution to produce this valuable compound from cheap renewable materials (e.g. vegetable oil). The specificity and enantioselectivity of the enzyme will provide the correct lactone Lacticaseibacillus rhamnosus
4.2.1.53 synthesis one of the largest bottlenecks in producing lactones is the hydroxylation of the fatty acids. The exploitation of oleate hydratase to hydrate oleic acid, which can easily be turned into gamma-dodecalactone after beta-elimination, is therefore the perfect solution to produce this valuable compound from cheap renewable materials (e.g. vegetable oil). The specificity and enantioselectivity of the enzyme will provide the correct lactone Lactiplantibacillus plantarum
4.2.1.53 synthesis one of the largest bottlenecks in producing lactones is the hydroxylation of the fatty acids. The exploitation of oleate hydratase to hydrate oleic acid, which can easily be turned into gamma-dodecalactone after beta-elimination, is therefore the perfect solution to produce this valuable compound from cheap renewable materials (e.g. vegetable oil). The specificity and enantioselectivity of the enzyme will provide the correct lactone Bifidobacterium breve
4.2.1.53 synthesis one of the largest bottlenecks in producing lactones is the hydroxylation of the fatty acids. The exploitation of oleate hydratase to hydrate oleic acid, which can easily be turned into gamma-dodecalactone after beta-elimination, is therefore the perfect solution to produce this valuable compound from cheap renewable materials (e.g. vegetable oil). The specificity and enantioselectivity of the enzyme will provide the correct lactone Bifidobacterium animalis subsp. lactis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.53 expression in Escherichia coli Lactobacillus acidophilus
4.2.1.53 expression in Escherichia coli Stenotrophomonas maltophilia
4.2.1.53 expression in Escherichia coli Elizabethkingia meningoseptica
4.2.1.53 expression in Escherichia coli Macrococcus caseolyticus
4.2.1.53 expression in Escherichia coli Streptococcus pyogenes
4.2.1.53 expression in Escherichia coli Lysinibacillus fusiformis
4.2.1.53 expression in Escherichia coli Lacticaseibacillus rhamnosus
4.2.1.53 expression in Escherichia coli Lactiplantibacillus plantarum
4.2.1.53 expression in Escherichia coli Bifidobacterium breve
4.2.1.53 expression in Escherichia coli Bifidobacterium animalis subsp. lactis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.53 67000
-
-
 Lactobacillus acidophilus
4.2.1.53 67000
-
-
 Stenotrophomonas maltophilia
4.2.1.53 67000
-
-
 Elizabethkingia meningoseptica
4.2.1.53 67000
-
-
 Macrococcus caseolyticus
4.2.1.53 67000
-
-
 Streptococcus pyogenes
4.2.1.53 67000
-
-
 Lysinibacillus fusiformis
4.2.1.53 67000
-
-
 Lacticaseibacillus rhamnosus
4.2.1.53 67000
-
-
 Lactiplantibacillus plantarum
4.2.1.53 67000
-
-
 Bifidobacterium breve
4.2.1.53 82000
-
-
 Bifidobacterium animalis subsp. lactis

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.53 Bifidobacterium animalis subsp. lactis A0A1C7FUY1
-
-
4.2.1.53 Bifidobacterium breve A0A2N6TXX1
-
-
4.2.1.53 Elizabethkingia meningoseptica C7DLJ6
-
-
4.2.1.53 Lacticaseibacillus rhamnosus A0A249DBU8
-
-
4.2.1.53 Lactiplantibacillus plantarum A0A0G9FDC3
-
-
4.2.1.53 Lactobacillus acidophilus
-
-
-
4.2.1.53 Lysinibacillus fusiformis A0A1E4R6K3
-
-
4.2.1.53 Macrococcus caseolyticus B9E972
-
-
4.2.1.53 Stenotrophomonas maltophilia
-
-
-
4.2.1.53 Streptococcus pyogenes B5XK69
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.53 (6Z,9Z,12Z)-octadec-6,9,12-trienoic acid + H2O
-
 Stenotrophomonas maltophilia (6Z,12Z)-10-hydroxyoctadec-6,12-dienoic acid
-
 ?
4.2.1.53 (6Z,9Z,12Z)-octadec-6,9,12-trienoic acid + H2O
-
 Macrococcus caseolyticus (6Z,12Z)-10-hydroxyoctadec-6,12-dienoic acid
-
 ?
4.2.1.53 (6Z,9Z,12Z)-octadec-6,9,12-trienoic acid + H2O
-
 Streptococcus pyogenes (6Z,12Z)-10-hydroxyoctadec-6,12-dienoic acid
-
 ?
4.2.1.53 (6Z,9Z,12Z)-octadec-6,9,12-trienoic acid + H2O
-
 Lysinibacillus fusiformis (6Z,12Z)-10-hydroxyoctadec-6,12-dienoic acid
-
 ?
4.2.1.53 (9Z)-hexadec-9-enoic acid + H2O
-
 Lactobacillus acidophilus 10-hydroxyhexadecanoic acid
-
 ?
4.2.1.53 (9Z)-hexadec-9-enoic acid + H2O
-
 Stenotrophomonas maltophilia 10-hydroxyhexadecanoic acid
-
 ?
4.2.1.53 (9Z)-hexadec-9-enoic acid + H2O
-
 Elizabethkingia meningoseptica 10-hydroxyhexadecanoic acid
-
 ?
4.2.1.53 (9Z)-hexadec-9-enoic acid + H2O
-
 Macrococcus caseolyticus 10-hydroxyhexadecanoic acid
-
 ?
4.2.1.53 (9Z)-hexadec-9-enoic acid + H2O
-
 Streptococcus pyogenes 10-hydroxyhexadecanoic acid
-
 ?
4.2.1.53 (9Z)-hexadec-9-enoic acid + H2O
-
 Lysinibacillus fusiformis 10-hydroxyhexadecanoic acid
-
 ?
4.2.1.53 (9Z)-hexadec-9-enoic acid + H2O
-
 Lacticaseibacillus rhamnosus 10-hydroxyhexadecanoic acid
-
 ?
4.2.1.53 (9Z)-hexadec-9-enoic acid + H2O
-
 Lactiplantibacillus plantarum 10-hydroxyhexadecanoic acid
-
 ?
4.2.1.53 (9Z)-hexadec-9-enoic acid + H2O
-
 Bifidobacterium breve 10-hydroxyhexadecanoic acid
-
 ?
4.2.1.53 (9Z)-hexadec-9-enoic acid + H2O
-
 Bifidobacterium animalis subsp. lactis 10-hydroxyhexadecanoic acid
-
 ?
4.2.1.53 (9Z)-octadec-9-enoic acid + H2O
-
 Stenotrophomonas maltophilia (R)-10-hydroxyoctadecanoic acid
-
 ?
4.2.1.53 (9Z)-octadec-9-enoic acid + H2O
-
 Macrococcus caseolyticus (R)-10-hydroxyoctadecanoic acid
-
 ?
4.2.1.53 (9Z)-octadec-9-enoic acid + H2O
-
 Streptococcus pyogenes (R)-10-hydroxyoctadecanoic acid
-
 ?
4.2.1.53 (9Z)-octadec-9-enoic acid + H2O
-
 Lysinibacillus fusiformis (R)-10-hydroxyoctadecanoic acid
-
 ?
4.2.1.53 (9Z,12Z)-octadec-9,12-dienoic acid + H2O
-
 Lactobacillus acidophilus (12Z)-10-hydroxyoctadec-12-enoic acid
-
 ?
4.2.1.53 (9Z,12Z)-octadec-9,12-dienoic acid + H2O
-
 Stenotrophomonas maltophilia (12Z)-10-hydroxyoctadec-12-enoic acid
-
 ?
4.2.1.53 (9Z,12Z)-octadec-9,12-dienoic acid + H2O
-
 Elizabethkingia meningoseptica (12Z)-10-hydroxyoctadec-12-enoic acid
-
 ?
4.2.1.53 (9Z,12Z)-octadec-9,12-dienoic acid + H2O
-
 Macrococcus caseolyticus (12Z)-10-hydroxyoctadec-12-enoic acid
-
 ?
4.2.1.53 (9Z,12Z)-octadec-9,12-dienoic acid + H2O
-
 Streptococcus pyogenes (12Z)-10-hydroxyoctadec-12-enoic acid
-
 ?
4.2.1.53 (9Z,12Z)-octadec-9,12-dienoic acid + H2O
-
 Lysinibacillus fusiformis (12Z)-10-hydroxyoctadec-12-enoic acid
-
 ?
4.2.1.53 (9Z,12Z)-octadec-9,12-dienoic acid + H2O
-
 Lacticaseibacillus rhamnosus (12Z)-10-hydroxyoctadec-12-enoic acid
-
 ?
4.2.1.53 (9Z,12Z)-octadec-9,12-dienoic acid + H2O
-
 Lactiplantibacillus plantarum (12Z)-10-hydroxyoctadec-12-enoic acid
-
 ?
4.2.1.53 (9Z,12Z)-octadec-9,12-dienoic acid + H2O
-
 Bifidobacterium breve (12Z)-10-hydroxyoctadec-12-enoic acid
-
 ?
4.2.1.53 (9Z,12Z)-octadec-9,12-dienoic acid + H2O
-
 Bifidobacterium animalis subsp. lactis (12Z)-10-hydroxyoctadec-12-enoic acid
-
 ?
4.2.1.53 (9Z,12Z,15Z)-octadec-9,12,15-trienoic acid + H2O
-
 Stenotrophomonas maltophilia (12Z,15Z)-10-hydroxyoctadec-12,15-dienoic acid
-
 ?
4.2.1.53 (9Z,12Z,15Z)-octadec-9,12,15-trienoic acid + H2O
-
 Elizabethkingia meningoseptica (12Z,15Z)-10-hydroxyoctadec-12,15-dienoic acid
-
 ?
4.2.1.53 (9Z,12Z,15Z)-octadec-9,12,15-trienoic acid + H2O
-
 Macrococcus caseolyticus (12Z,15Z)-10-hydroxyoctadec-12,15-dienoic acid
-
 ?
4.2.1.53 (9Z,12Z,15Z)-octadec-9,12,15-trienoic acid + H2O
-
 Streptococcus pyogenes (12Z,15Z)-10-hydroxyoctadec-12,15-dienoic acid
-
 ?
4.2.1.53 (9Z,12Z,15Z)-octadec-9,12,15-trienoic acid + H2O
-
 Lysinibacillus fusiformis (12Z,15Z)-10-hydroxyoctadec-12,15-dienoic acid
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.1.53 dimer
-
 Stenotrophomonas maltophilia
4.2.1.53 dimer
-
 Macrococcus caseolyticus
4.2.1.53 dimer
-
 Streptococcus pyogenes
4.2.1.53 dimer
-
 Lysinibacillus fusiformis

Synonyms

EC Number Synonyms Comment Organism
4.2.1.53 OHase
-
 Lactobacillus acidophilus
4.2.1.53 OHase
-
 Stenotrophomonas maltophilia
4.2.1.53 OHase
-
 Elizabethkingia meningoseptica
4.2.1.53 OHase
-
 Macrococcus caseolyticus
4.2.1.53 OHase
-
 Streptococcus pyogenes
4.2.1.53 OHase
-
 Lysinibacillus fusiformis
4.2.1.53 OHase
-
 Lacticaseibacillus rhamnosus
4.2.1.53 OHase
-
 Lactiplantibacillus plantarum
4.2.1.53 OHase
-
 Bifidobacterium breve
4.2.1.53 OHase
-
 Bifidobacterium animalis subsp. lactis

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.53 FAD with the multiple sequence alignment a motif indicative of FAD binding is identified Lactobacillus acidophilus
4.2.1.53 FAD with the multiple sequence alignment a motif indicative of FAD binding is identified Stenotrophomonas maltophilia
4.2.1.53 FAD with the multiple sequence alignment a motif indicative of FAD binding is identified Elizabethkingia meningoseptica
4.2.1.53 FAD with the multiple sequence alignment a motif indicative of FAD binding is identified Macrococcus caseolyticus
4.2.1.53 FAD with the multiple sequence alignment a motif indicative of FAD binding is identified Streptococcus pyogenes
4.2.1.53 FAD with the multiple sequence alignment a motif indicative of FAD binding is identified Lysinibacillus fusiformis
4.2.1.53 FAD with the multiple sequence alignment a motif indicative of FAD binding is identified Lacticaseibacillus rhamnosus
4.2.1.53 FAD with the multiple sequence alignment a motif indicative of FAD binding is identified Lactiplantibacillus plantarum
4.2.1.53 FAD with the multiple sequence alignment a motif indicative of FAD binding is identified Bifidobacterium breve
4.2.1.53 FAD with the multiple sequence alignment a motif indicative of FAD binding is identified Bifidobacterium animalis subsp. lactis