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Literature summary extracted from

  • Esparza-Molto, P.B.; Nuevo-Tapioles, C.; Cuezva, J.M.
    Regulation of the H+-ATP synthase by IF1 a role in mitohormesis (2017), Cell. Mol. Life Sci., 74, 2151-2166 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.2.2 2-hydroxyglutarate
-
 Saccharomyces cerevisiae
7.1.2.2 2-oxoglutarate
-
 Saccharomyces cerevisiae
7.1.2.2 ATPase inhibitory factor 1 physiological inhibitor Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.2.2 mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.1.2.2 Ca2+ activates Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.2.2 ATP + H2O + 4 H+[side 1] Saccharomyces cerevisiae
-
 ADP + phosphate + 4 H+[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.1.2.2 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.2.2 ATP + H2O + 4 H+[side 1]
-
 Saccharomyces cerevisiae ADP + phosphate + 4 H+[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.2.2 H+-ATP synthase the multisubunit complex is built by two major functional domains: the membrane-embedded Fo-ATPase (a and 8c subunits) and the membrane extrinsic catalytic F1-ATPase (3alpha, 3beta, gamma, delta and epsilon subunits) domains Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
7.1.2.2 metabolism the enzyme modulates signaling pathways that activate the mitohormetic response, namely ATP, reactive oxygen species, and target of rapamycin Saccharomyces cerevisiae