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Literature summary extracted from

  • Gooding, J.R.; Jensen, M.V.; Dai, X.; Wenner, B.R.; Lu, D.; Arumugam, R.; Ferdaoussi, M.; MacDonald, P.E.; Newgard, C.B.
    Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolism (2015), Cell Rep., 13, 157-167 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.2.2 (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate Rattus norvegicus
-
 fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?
4.3.2.2 N6-(1,2-dicarboxyethyl)AMP Rattus norvegicus
-
 fumarate + AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.3.2.2 Rattus norvegicus D3ZW08
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.3.2.2 INS-1 823/13 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.2.2 (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 Rattus norvegicus fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
 ?
4.3.2.2 N6-(1,2-dicarboxyethyl)AMP
-
 Rattus norvegicus fumarate + AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.3.2.2 ADSL
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
4.3.2.2 Rattus norvegicus pharmacologic or molecular inhibition of adenylosuccinate synthase expression impairs glucose-stimulated insulin secretion from islet beta-cells down

General Information

EC Number General Information Comment Organism
4.3.2.2 malfunction knockdown of adenylosuccinate lyase causes small increases in AMP, ADP and ATP levels. It does not result in decreases in other adenine nucleotides Rattus norvegicus
4.3.2.2 metabolism glucose-induced flux through de novo purine synthesis and adenylosuccinate synthase 2 drive increases in adenylosuccinate levels in beta-cells, causing enhanced insulin granule exocytosis Rattus norvegicus
4.3.2.2 metabolism the enzyme plays two important roles in nucleotide metabolism, serving first to catalyze a proximal step in the purine biosynthetic pathway, the conversion of SAICAR to AICAR (ZMP), and then also acting to degrade S-AMP to AMP and fumarate more distally Rattus norvegicus