EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
5.1.3.8 | ATP | over 4fold activation at 2 mM | Pedobacter heparinus | |
5.1.3.8 | additional information | no effects by nucleotides AMP, ADP, GMP, GDP, GTP, CMP, CTP, and UTP at 2 mM each | Pedobacter heparinus |
EC Number | Application | Comment | Organism |
---|---|---|---|
5.1.3.8 | additional information | the mammalian enzyme is a target for development inhibitors for sialic acid biosynthesis | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.1.3.8 | 2-mercaptoethanol | 30% inhibition at 10 mM, 40% at 100 mM | Pedobacter heparinus | |
5.1.3.8 | SDS | 40% inhibition at 1% | Pedobacter heparinus | |
5.1.3.8 | Triton X-100 | 30% inhibition at 0.1%, 20% at 1% | Pedobacter heparinus | |
5.1.3.8 | Urea | 50% inhibition at 2 M, 10% at 1 M | Pedobacter heparinus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.1.3.8 | N-acetyl-D-glucosamine | Homo sapiens | - |
N-acetyl-D-mannosamine | - |
r | |
5.1.3.8 | N-acetyl-D-glucosamine | Pedobacter heparinus | - |
N-acetyl-D-mannosamine | - |
r | |
5.1.3.8 | N-acetyl-D-glucosamine | Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3 | - |
N-acetyl-D-mannosamine | - |
r | |
5.1.3.8 | N-Acyl-D-glucosamine | Homo sapiens | - |
N-Acyl-D-mannosamine | - |
r | |
5.1.3.8 | N-Acyl-D-glucosamine | Pedobacter heparinus | - |
N-Acyl-D-mannosamine | - |
r | |
5.1.3.8 | N-Acyl-D-glucosamine | Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3 | - |
N-Acyl-D-mannosamine | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.1.3.8 | Homo sapiens | P51606 | - |
- |
5.1.3.8 | Pedobacter heparinus | C6Y403 | - |
- |
5.1.3.8 | Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3 | C6Y403 | - |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
5.1.3.8 | N-acyl-D-glucosamine = N-acyl-D-mannosamine | various amino acid residues of the enzyme are involved in the reaction mechanism | Homo sapiens | |
5.1.3.8 | N-acyl-D-glucosamine = N-acyl-D-mannosamine | various amino acid residues of the enzyme are involved in the reaction mechanism | Pedobacter heparinus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
5.1.3.8 | kidney | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.1.3.8 | N-acetyl-D-glucosamine | - |
Homo sapiens | N-acetyl-D-mannosamine | - |
r | |
5.1.3.8 | N-acetyl-D-glucosamine | - |
Pedobacter heparinus | N-acetyl-D-mannosamine | - |
r | |
5.1.3.8 | N-acetyl-D-glucosamine | - |
Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3 | N-acetyl-D-mannosamine | - |
r | |
5.1.3.8 | N-Acyl-D-glucosamine | - |
Homo sapiens | N-Acyl-D-mannosamine | - |
r | |
5.1.3.8 | N-Acyl-D-glucosamine | - |
Pedobacter heparinus | N-Acyl-D-mannosamine | - |
r | |
5.1.3.8 | N-Acyl-D-glucosamine | - |
Pedobacter heparinus ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3 | N-Acyl-D-mannosamine | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.1.3.8 | GlcNAc 2-epimerase | - |
Homo sapiens |
5.1.3.8 | GlcNAc 2-epimerase | - |
Pedobacter heparinus |
5.1.3.8 | N-Acetylglucosamine 2-epimerase | - |
Homo sapiens |
5.1.3.8 | N-Acetylglucosamine 2-epimerase | - |
Pedobacter heparinus |
5.1.3.8 | PhGn2E | - |
Pedobacter heparinus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
5.1.3.8 | NTP | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
5.1.3.8 | evolution | mammalian enzyme requires the presence of nucleotide activators and cofactors, while the bacterial enzyme are activated by nucleotide binding, but do not require them as cofactors | Homo sapiens |
5.1.3.8 | evolution | mammalian enzyme requires the presence of nucleotide activators and cofactors, while the bacterial enzyme are activated by nucleotide binding, but do not require them as cofactors | Pedobacter heparinus |
5.1.3.8 | metabolism | the biosynthesis of N-acetyl-D-mannosamine can be regulated in amammals in two different ways. In the liver, UDP-GlcNAc is epimerized to UDP-ManNAc by the bifunctional UDP-GlcNAc 2-epimerase, while in the kidney (mostly), GlcNAc is directly epimerized to ManNac by GlyNAc 2-epimerase | Homo sapiens |