BRENDA - Enzyme Database

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance A review of the past decade

Chen, Z.; Shi, T.; Zhang, L.; Zhu, P.; Deng, M.; Huang, C.; Hu, T.; Jiang, L.; Li, J.; Cancer Lett. 370, 153-164 (2016)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
7.6.2.2
amlodipine
-
Homo sapiens
7.6.2.2
atorvastatin
-
Homo sapiens
7.6.2.2
azithromycin
-
Homo sapiens
7.6.2.2
cyclosporin A
-
Homo sapiens
7.6.2.2
dexniguldipine
-
Homo sapiens
7.6.2.2
dipyridamole
-
Homo sapiens
7.6.2.2
Disulfiram
-
Homo sapiens
7.6.2.2
elacridar
-
Homo sapiens
7.6.2.2
fumitremorgin C
-
Homo sapiens
7.6.2.2
Furosemide
-
Homo sapiens
7.6.2.2
GF120918
-
Homo sapiens
7.6.2.2
glibenclamide
-
Homo sapiens
7.6.2.2
LY335979
-
Homo sapiens
7.6.2.2
LY475776
-
Homo sapiens
7.6.2.2
MK-571
-
Homo sapiens
7.6.2.2
MS-209
-
Homo sapiens
7.6.2.2
nifedipine
-
Homo sapiens
7.6.2.2
novobiocin
-
Homo sapiens
7.6.2.2
OC144-093
-
Homo sapiens
7.6.2.2
ortataxel
-
Homo sapiens
7.6.2.2
pluronic L61
-
Homo sapiens
7.6.2.2
probenecid
-
Homo sapiens
7.6.2.2
PSC-833
-
Homo sapiens
7.6.2.2
quinidine
-
Homo sapiens
7.6.2.2
R101933
-
Homo sapiens
7.6.2.2
reserpine
-
Homo sapiens
7.6.2.2
ritonavir
-
Homo sapiens
7.6.2.2
S9788
-
Homo sapiens
7.6.2.2
tariquidar
-
Homo sapiens
7.6.2.2
V-104
-
Homo sapiens
7.6.2.2
verapamil
-
Homo sapiens
7.6.2.2
VX-710
-
Homo sapiens
7.6.2.2
XR-9576
-
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
7.6.2.2
plasma membrane
-
Homo sapiens
5886
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
7.6.2.2
ATP + H2O + xenobiotic[side 1]
Homo sapiens
-
ADP + phosphate + xenobiotic[side 2]
-
-
?
Organism
EC Number
Organism
UniProt
Commentary
Textmining
7.6.2.2
Homo sapiens
-
-
-
7.6.2.2
Homo sapiens
P08183
-
-
7.6.2.2
Homo sapiens
Q2M3G0
-
-
7.6.2.2
Homo sapiens
Q92887
-
-
7.6.2.2
Homo sapiens
Q9UNQ0
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
7.6.2.2
brain
-
Homo sapiens
-
7.6.2.2
brain capillary endothelial cell line
-
Homo sapiens
-
7.6.2.2
culture condition:CD4+ cell
-
Homo sapiens
-
7.6.2.2
enterocyte
-
Homo sapiens
-
7.6.2.2
gall bladder
-
Homo sapiens
-
7.6.2.2
hepatocyte
-
Homo sapiens
-
7.6.2.2
intestinal mucosa
-
Homo sapiens
-
7.6.2.2
intestine
-
Homo sapiens
-
7.6.2.2
kidney
-
Homo sapiens
-
7.6.2.2
liver
-
Homo sapiens
-
7.6.2.2
lymphocyte
-
Homo sapiens
-
7.6.2.2
placenta
-
Homo sapiens
-
7.6.2.2
renal proximal tubule epithelial cell
-
Homo sapiens
-
7.6.2.2
small intestine
-
Homo sapiens
-
7.6.2.2
trophoblast
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
7.6.2.2
ATP + H2O + 4-aminohippurate[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + 4-aminohippurate[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + 5-fluorouracil[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + 5-fluorouracil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + actinomycin D[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + actinomycin D[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + adevovir[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + adevovir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + amiodarone[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + amiodarone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ampicillin[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + ampicillin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + amprenavir[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + amprenavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + asimadoline[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + asimadoline[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + azidopine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + azidopine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + azidothymidine[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + azidothymidine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + azithromycin[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + azithromycin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + BCECF-acetoxymethylester[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + BCECF-acetoxymethylester[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + bepridil[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + bepridil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + bisantrene[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + bisantrene[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + calcein acetoxymethylester[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + calcein acetoxymethylester[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + calcein-acetoxymethylester[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + calcein-acetoxymethylester[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cefodizime[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + cefodizime[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cefoperazone[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + cefoperazone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ceftriaxone[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + ceftriaxone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ceftriaxone[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + ceftriaxone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cerivastatin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + cerivastatin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + chlorambucil[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + chlorambucil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + chlorpromazine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + chlorpromazine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + chrysin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + chrysin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cidofovir[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + cidofovir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cimetidine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + cimetidine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ciprofloxacin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + ciprofloxacin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cisplatin[side 1]
substrate for P-glycoprotein and MPR2
747448
Homo sapiens
ADP + phosphate + cisplatin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + clarithromycin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + clarithromycin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + colchicine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + colchicine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cyclosporin A[side 1]
substrate for P-glycoprotein and BCRP
747448
Homo sapiens
ADP + phosphate + cyclosporin A[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cyclosporin H[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + cyclosporin H[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cytarabine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + cytarabine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + daunorubicin[side 1]
substrate for P-glycoprotein and BCRP
747448
Homo sapiens
ADP + phosphate + daunorubicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + delavirdine[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + delavirdine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + digoxin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + digoxin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + diltiazem[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + diltiazem[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + docetaxel[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + docetaxel[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + doxorubicin[side 1]
substrate for P-glycoprotein, BCRP, and MPR2
747448
Homo sapiens
ADP + phosphate + doxorubicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + doxycycline[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + doxycycline[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + endosulfan[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + endosulfan[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + epirubicin[side 1]
substrate for P-glycoprotein, BCRP, and MPR2
747448
Homo sapiens
ADP + phosphate + epirubicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + erythromycin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + erythromycin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ethinylestradiol-3-O-glucuronide[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + ethinylestradiol-3-O-glucuronide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + etoposide[side 1]
substrate for P-glycoprotein, BCRP, and MPR2
747448
Homo sapiens
ADP + phosphate + etoposide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + felodipine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + felodipine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + fentanyl[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + fentanyl[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + fexofenadine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + fexofenadine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + FK506[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + FK506[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + gefitinib[side 1]
substrate for P-glycoprotein and BCRP
747448
Homo sapiens
ADP + phosphate + gefitinib[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + genistein-7-glucoside[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + genistein-7-glucoside[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + gramicidin A[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + gramicidin A[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + gramicidin D[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + gramicidin D[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + grepafloxacine[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + grepafloxacine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + grepafloxacin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + grepafloxacin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + Hoechst 33342[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + Hoechst 33342[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + hydroxyurea[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + hydroxyurea[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + imatinib[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + imatinib[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + indinavir[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + indinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + indinavir[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + indinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + irinotecan[side 1]
substrate for P-glycoprotein, BCRP, and MPR2
747448
Homo sapiens
ADP + phosphate + irinotecan[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + itraconazole[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + itraconazole[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ketoconazole[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + ketoconazole[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + lamivudine[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + lamivudine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + leupeptin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + leupeptin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + levofloxacin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + levofloxacin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + lidocaine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + lidocaine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + lopinavir[side 1]
substrate for MPR2 and BCRP
747448
Homo sapiens
ADP + phosphate + lopinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + lopinavir[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + lopinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + lovastatin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + lovastatin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + methotrexate[side 1]
substrate for P-glycoprotein, BCRP, and MPR2
747448
Homo sapiens
ADP + phosphate + methotrexate[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + methyl parathion[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + methyl parathion[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + mitomycin C[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + mitomycin C[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + mitoxantrone[side 1]
substrate for P-glycoprotein, BCRP, and MPR2
747448
Homo sapiens
ADP + phosphate + mitoxantrone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + morphine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + morphine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + nelfinavir[side 1]
substrate for MPR2 and BCRP
747448
Homo sapiens
ADP + phosphate + nelfinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + nelfinavir[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + nelfinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + nicardipine[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + nicardipine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + nifedipine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + nifedipine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + nisoldipine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + nisoldipine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + nitrendipine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + nitrendipine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + norfloxacin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + norfloxacin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ofloxacin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + ofloxacin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + olmesartan[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + olmesartan[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ortataxel[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + ortataxel[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + paraquat[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + paraquat[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + pentazocine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + pentazocine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + pepstatin A[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + pepstatin A[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + phenothiazine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + phenothiazine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + phloridzin[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + phloridzin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + pravastatin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + pravastatin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + propafenone[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + propafenone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + quercetin 4'-beta-glucoside[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + quercetin 4'-beta-glucoside[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + quercetin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + quercetin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + quinidine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + quinidine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ranitidine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + ranitidine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + reserpine[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + reserpine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + rhodamine 123[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + rhodamine 123[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + rifampicin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + rifampicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ritonavir[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + ritonavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ritonavir[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + ritonavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + rosuvastatin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + rosuvastatin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + saquinavir[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + saquinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + saquinavir[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + saquinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + simvastatin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + simvastatin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + sirolimus[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + sirolimus[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + SN-38[side 1]
substrate for MPR2 and BCRP
747448
Homo sapiens
ADP + phosphate + SN-38[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + sparfloxacin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + sparfloxacin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + tacrolimus[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + tacrolimus[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + tamoxifen[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + tamoxifen[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + temocaprilate[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + temocaprilate[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + teniposide[side 1]
substrate for P-glycoprotein and BCRP
747448
Homo sapiens
ADP + phosphate + teniposide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + terfenadine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + terfenadine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + tetracycline[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + tetracycline[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + tiapamil[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + tiapamil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + topotecan[side 1]
substrate for P-glycoprotein and BCRP
747448
Homo sapiens
ADP + phosphate + topotecan[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + trans-flupentixol[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + trans-flupentixol[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + trifluoperazine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + trifluoperazine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + valinomycin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + valinomycin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + valspodar[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + valspodar[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + verapamil[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + verapamil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + vinblastine[side 1]
substrate for P-glycoprotein and MPR2
747448
Homo sapiens
ADP + phosphate + vinblastine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + vincristine[side 1]
substrate for P-glycoprotein and MPR2
747448
Homo sapiens
ADP + phosphate + vincristine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + xenobiotic[side 1]
-
747448
Homo sapiens
ADP + phosphate + xenobiotic[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + zidovudine[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + zidovudine[side 2]
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
7.6.2.2
?
x * 170000, P-glycoprotein , SDS-PAGE; x * 170000, P-glycoprotein , SDS-PAGE; x * 170000, P-glycoprotein , SDS-PAGE; x * 170000, P-glycoprotein , SDS-PAGE; x * 170000, P-glycoprotein , SDS-PAGE
Homo sapiens
Synonyms
EC Number
Synonyms
Commentary
Organism
7.6.2.2
ABCB1
-
Homo sapiens
7.6.2.2
ABCC2
-
Homo sapiens
7.6.2.2
ABCG2
-
Homo sapiens
7.6.2.2
BCRP
-
Homo sapiens
7.6.2.2
breast cancer resistance protein
-
Homo sapiens
7.6.2.2
canalicular multispecific organic anion transporter
-
Homo sapiens
7.6.2.2
MDR-ABC transporter
-
Homo sapiens
7.6.2.2
MOAT
-
Homo sapiens
7.6.2.2
MRP2
-
Homo sapiens
7.6.2.2
multidrug resistance-associated protein 2
-
Homo sapiens
7.6.2.2
P-glycoprotein
-
Homo sapiens
7.6.2.2
P-gp
-
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
7.6.2.2
amlodipine
-
Homo sapiens
7.6.2.2
atorvastatin
-
Homo sapiens
7.6.2.2
azithromycin
-
Homo sapiens
7.6.2.2
cyclosporin A
-
Homo sapiens
7.6.2.2
dexniguldipine
-
Homo sapiens
7.6.2.2
dipyridamole
-
Homo sapiens
7.6.2.2
Disulfiram
-
Homo sapiens
7.6.2.2
elacridar
-
Homo sapiens
7.6.2.2
fumitremorgin C
-
Homo sapiens
7.6.2.2
Furosemide
-
Homo sapiens
7.6.2.2
GF120918
-
Homo sapiens
7.6.2.2
glibenclamide
-
Homo sapiens
7.6.2.2
LY335979
-
Homo sapiens
7.6.2.2
LY475776
-
Homo sapiens
7.6.2.2
MK-571
-
Homo sapiens
7.6.2.2
MS-209
-
Homo sapiens
7.6.2.2
nifedipine
-
Homo sapiens
7.6.2.2
novobiocin
-
Homo sapiens
7.6.2.2
OC144-093
-
Homo sapiens
7.6.2.2
ortataxel
-
Homo sapiens
7.6.2.2
pluronic L61
-
Homo sapiens
7.6.2.2
probenecid
-
Homo sapiens
7.6.2.2
PSC-833
-
Homo sapiens
7.6.2.2
quinidine
-
Homo sapiens
7.6.2.2
R101933
-
Homo sapiens
7.6.2.2
reserpine
-
Homo sapiens
7.6.2.2
ritonavir
-
Homo sapiens
7.6.2.2
S9788
-
Homo sapiens
7.6.2.2
tariquidar
-
Homo sapiens
7.6.2.2
V-104
-
Homo sapiens
7.6.2.2
verapamil
-
Homo sapiens
7.6.2.2
VX-710
-
Homo sapiens
7.6.2.2
XR-9576
-
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
7.6.2.2
plasma membrane
-
Homo sapiens
5886
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
7.6.2.2
ATP + H2O + xenobiotic[side 1]
Homo sapiens
-
ADP + phosphate + xenobiotic[side 2]
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
7.6.2.2
brain
-
Homo sapiens
-
7.6.2.2
brain capillary endothelial cell line
-
Homo sapiens
-
7.6.2.2
culture condition:CD4+ cell
-
Homo sapiens
-
7.6.2.2
enterocyte
-
Homo sapiens
-
7.6.2.2
gall bladder
-
Homo sapiens
-
7.6.2.2
hepatocyte
-
Homo sapiens
-
7.6.2.2
intestinal mucosa
-
Homo sapiens
-
7.6.2.2
intestine
-
Homo sapiens
-
7.6.2.2
kidney
-
Homo sapiens
-
7.6.2.2
liver
-
Homo sapiens
-
7.6.2.2
lymphocyte
-
Homo sapiens
-
7.6.2.2
placenta
-
Homo sapiens
-
7.6.2.2
renal proximal tubule epithelial cell
-
Homo sapiens
-
7.6.2.2
small intestine
-
Homo sapiens
-
7.6.2.2
trophoblast
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
7.6.2.2
ATP + H2O + 4-aminohippurate[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + 4-aminohippurate[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + 5-fluorouracil[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + 5-fluorouracil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + actinomycin D[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + actinomycin D[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + adevovir[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + adevovir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + amiodarone[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + amiodarone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ampicillin[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + ampicillin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + amprenavir[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + amprenavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + asimadoline[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + asimadoline[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + azidopine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + azidopine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + azidothymidine[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + azidothymidine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + azithromycin[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + azithromycin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + BCECF-acetoxymethylester[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + BCECF-acetoxymethylester[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + bepridil[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + bepridil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + bisantrene[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + bisantrene[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + calcein acetoxymethylester[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + calcein acetoxymethylester[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + calcein-acetoxymethylester[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + calcein-acetoxymethylester[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cefodizime[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + cefodizime[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cefoperazone[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + cefoperazone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ceftriaxone[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + ceftriaxone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ceftriaxone[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + ceftriaxone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cerivastatin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + cerivastatin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + chlorambucil[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + chlorambucil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + chlorpromazine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + chlorpromazine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + chrysin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + chrysin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cidofovir[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + cidofovir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cimetidine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + cimetidine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ciprofloxacin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + ciprofloxacin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cisplatin[side 1]
substrate for P-glycoprotein and MPR2
747448
Homo sapiens
ADP + phosphate + cisplatin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + clarithromycin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + clarithromycin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + colchicine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + colchicine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cyclosporin A[side 1]
substrate for P-glycoprotein and BCRP
747448
Homo sapiens
ADP + phosphate + cyclosporin A[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cyclosporin H[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + cyclosporin H[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + cytarabine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + cytarabine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + daunorubicin[side 1]
substrate for P-glycoprotein and BCRP
747448
Homo sapiens
ADP + phosphate + daunorubicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + delavirdine[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + delavirdine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + digoxin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + digoxin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + diltiazem[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + diltiazem[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + docetaxel[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + docetaxel[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + doxorubicin[side 1]
substrate for P-glycoprotein, BCRP, and MPR2
747448
Homo sapiens
ADP + phosphate + doxorubicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + doxycycline[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + doxycycline[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + endosulfan[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + endosulfan[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + epirubicin[side 1]
substrate for P-glycoprotein, BCRP, and MPR2
747448
Homo sapiens
ADP + phosphate + epirubicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + erythromycin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + erythromycin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ethinylestradiol-3-O-glucuronide[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + ethinylestradiol-3-O-glucuronide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + etoposide[side 1]
substrate for P-glycoprotein, BCRP, and MPR2
747448
Homo sapiens
ADP + phosphate + etoposide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + felodipine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + felodipine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + fentanyl[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + fentanyl[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + fexofenadine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + fexofenadine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + FK506[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + FK506[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + gefitinib[side 1]
substrate for P-glycoprotein and BCRP
747448
Homo sapiens
ADP + phosphate + gefitinib[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + genistein-7-glucoside[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + genistein-7-glucoside[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + gramicidin A[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + gramicidin A[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + gramicidin D[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + gramicidin D[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + grepafloxacine[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + grepafloxacine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + grepafloxacin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + grepafloxacin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + Hoechst 33342[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + Hoechst 33342[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + hydroxyurea[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + hydroxyurea[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + imatinib[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + imatinib[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + indinavir[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + indinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + indinavir[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + indinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + irinotecan[side 1]
substrate for P-glycoprotein, BCRP, and MPR2
747448
Homo sapiens
ADP + phosphate + irinotecan[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + itraconazole[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + itraconazole[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ketoconazole[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + ketoconazole[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + lamivudine[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + lamivudine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + leupeptin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + leupeptin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + levofloxacin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + levofloxacin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + lidocaine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + lidocaine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + lopinavir[side 1]
substrate for MPR2 and BCRP
747448
Homo sapiens
ADP + phosphate + lopinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + lopinavir[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + lopinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + lovastatin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + lovastatin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + methotrexate[side 1]
substrate for P-glycoprotein, BCRP, and MPR2
747448
Homo sapiens
ADP + phosphate + methotrexate[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + methyl parathion[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + methyl parathion[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + mitomycin C[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + mitomycin C[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + mitoxantrone[side 1]
substrate for P-glycoprotein, BCRP, and MPR2
747448
Homo sapiens
ADP + phosphate + mitoxantrone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + morphine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + morphine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + nelfinavir[side 1]
substrate for MPR2 and BCRP
747448
Homo sapiens
ADP + phosphate + nelfinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + nelfinavir[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + nelfinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + nicardipine[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + nicardipine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + nifedipine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + nifedipine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + nisoldipine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + nisoldipine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + nitrendipine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + nitrendipine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + norfloxacin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + norfloxacin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ofloxacin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + ofloxacin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + olmesartan[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + olmesartan[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ortataxel[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + ortataxel[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + paraquat[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + paraquat[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + pentazocine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + pentazocine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + pepstatin A[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + pepstatin A[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + phenothiazine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + phenothiazine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + phloridzin[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + phloridzin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + pravastatin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + pravastatin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + propafenone[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + propafenone[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + quercetin 4'-beta-glucoside[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + quercetin 4'-beta-glucoside[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + quercetin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + quercetin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + quinidine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + quinidine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ranitidine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + ranitidine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + reserpine[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + reserpine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + rhodamine 123[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + rhodamine 123[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + rifampicin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + rifampicin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ritonavir[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + ritonavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + ritonavir[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + ritonavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + rosuvastatin[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + rosuvastatin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + saquinavir[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + saquinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + saquinavir[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + saquinavir[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + simvastatin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + simvastatin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + sirolimus[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + sirolimus[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + SN-38[side 1]
substrate for MPR2 and BCRP
747448
Homo sapiens
ADP + phosphate + SN-38[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + sparfloxacin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + sparfloxacin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + tacrolimus[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + tacrolimus[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + tamoxifen[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + tamoxifen[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + temocaprilate[side 1]
substrate for MPR2
747448
Homo sapiens
ADP + phosphate + temocaprilate[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + teniposide[side 1]
substrate for P-glycoprotein and BCRP
747448
Homo sapiens
ADP + phosphate + teniposide[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + terfenadine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + terfenadine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + tetracycline[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + tetracycline[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + tiapamil[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + tiapamil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + topotecan[side 1]
substrate for P-glycoprotein and BCRP
747448
Homo sapiens
ADP + phosphate + topotecan[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + trans-flupentixol[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + trans-flupentixol[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + trifluoperazine[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + trifluoperazine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + valinomycin[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + valinomycin[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + valspodar[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + valspodar[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + verapamil[side 1]
substrate for P-glycoprotein
747448
Homo sapiens
ADP + phosphate + verapamil[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + vinblastine[side 1]
substrate for P-glycoprotein and MPR2
747448
Homo sapiens
ADP + phosphate + vinblastine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + vincristine[side 1]
substrate for P-glycoprotein and MPR2
747448
Homo sapiens
ADP + phosphate + vincristine[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + xenobiotic[side 1]
-
747448
Homo sapiens
ADP + phosphate + xenobiotic[side 2]
-
-
-
?
7.6.2.2
ATP + H2O + zidovudine[side 1]
substrate for BCRP
747448
Homo sapiens
ADP + phosphate + zidovudine[side 2]
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
7.6.2.2
?
x * 170000, P-glycoprotein , SDS-PAGE
Homo sapiens