Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Gutowska-Owsiak, D.; Greenwald, L.; Watson, C.; Selvakumar, T.A.; Wang, X.; Ogg, G.S.
    The histamine-synthesizing enzyme histidine decarboxylase is upregulated by keratinocytes in atopic skin (2014), Br. J. Dermatol., 171, 771-778 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.22 quantitative PCR enzyme expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.22 L-histidine Homo sapiens
-
 histamine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Homo sapiens P19113
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.22 epidermis
-
 Homo sapiens
-
4.1.1.22 HaCaT cell
-
 Homo sapiens
-
4.1.1.22 keratinocyte two-dimensional culture Homo sapiens
-
4.1.1.22 additional information keratinocytes express abundant HDC protein, and the levels increase in atopic skin Homo sapiens
-
4.1.1.22 skin atopic Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-histidine
-
 Homo sapiens histamine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.22 HDC
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
4.1.1.22 Homo sapiens ultraviolet B and surfactant exposure induce the expression of histamine-synthesizing enzyme histidine decarboxylase in keratinocytes. Lipopolysaccharide, house dust mite (HDM) extract, and cytokines, which are implicated in allergic inflammation, promote the expression of the enzyme and upregulate histamine levels in keratinocytes up

General Information

EC Number General Information Comment Organism
4.1.1.22 malfunction filaggrin expression in cultured keratinocytes increased following histamine depletion. Histidine decarboxylase expression is increased in the epidermis of patients with eczema Homo sapiens
4.1.1.22 physiological function lipopolysaccharide, house dust mite (HDM) extract, and cytokines, which are implicated in allergic inflammation, promote the expression of the enzyme and upregulate histamine levels in keratinocytes. Actively produced histamine influences keratinocyte differentiation, suggesting functional relevance of the axis to atopic dermatitis. HDC expression in keratinocytes is increased in atopic dermatitis Homo sapiens