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Literature summary extracted from

  • Xu, F.; Jerlstroem-Hultqvist, J.; Kolisko, M.; Simpson, A.; Roger, A.; Svaerd, S.; Andersson, J.
    On the reversibility of parasitism adaptation to a free-living lifestyle via gene acquisitions in the diplomonad Trepomonas sp. PC1 (2016), BMC Biol., 14, 62 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.2.1.123 diagnostics tetrahymanol is a polycyclic triterpenoid lipid in the Tetrahymena ciliates. The diagenetic product, gammacerane, is often used as a biomarker for water column stratification in ancient ecosystems Trepomonas sp. PC1

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.123 gene TPC1_17222, sequence comparisons and phylogenetic analysis, transcriptome analysis Trepomonas sp. PC1

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.123 squalene + H2O Trepomonas sp. PC1
-
tetrahymanol
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.123 Trepomonas sp. PC1 A0A146K6G2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.123 squalene + H2O
-
Trepomonas sp. PC1 tetrahymanol
-
?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.123 squalene-tetrahymanol cyclase
-
Trepomonas sp. PC1
4.2.1.123 STC
-
Trepomonas sp. PC1
4.2.1.123 TPC1_17222
-
Trepomonas sp. PC1

General Information

EC Number General Information Comment Organism
4.2.1.123 evolution phylogenetic evidence reveals that the last common ancestor of diplomonads was dependent on a host and that Trepomonas has adapted secondarily to a free-living lifestyle. Free-living taxa are nested within parasites reveals more examples of secondarily free-living eukaryotes, transcriptome study of Trepomonas sp. PC1, a diplomonad isolated from marine sediment. Phylogenetic analyses show that most of the differences in metabolic capacity between free-living Trepomonas and the parasitic diplomonads are due to recent acquisitions of bacterial genes via gene transfer. The transcriptome includes a gene encoding squalene-tetrahymanol cyclase. This enzyme synthesizes the sterol substitute tetrahymanol in the absence of oxygen, potentially allowing Trepomonas to thrive under anaerobic conditions as a free-living bacterivore, without depending on sterols from other eukaryotes Trepomonas sp. PC1
4.2.1.123 physiological function the enzyme synthesizes the sterol substitute tetrahymanol in the absence of oxygen, potentially allowing Trepomonas to thrive under anaerobic conditions as a free-living bacterivore, without depending on sterols from other eukaryotes. Several microbial eukaryotes that live under anoxic conditions employ the sterol substitute tetrahymanol, which can be synthesized without molecular oxygen. The Trepomonas transcriptome includes a homologue of STC, the enzyme required to synthesize tetrahymanol Trepomonas sp. PC1