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Literature summary extracted from

  • Watanabe, S.; Ozawa, H.; Kato, H.; Nimura-Matsune, K.; Hirayama, T.; Kudo, F.; Eguchi, T.; Kakinuma, K.; Yoshikawa, H.
    Carbon-free production of 2-deoxy-scyllo-inosose (DOI) in cyanobacterium Synechococcus elongatus PCC 7942 (2018), Biosci. Biotechnol. Biochem., 82, 161-165 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.3.124 gene btrC, functional recombinant expression in Synechococcus elongatus strain PCC 7942 Niallia circulans

Protein Variants

EC Number Protein Variants Comment Organism
4.2.3.124 additional information transgenic production of 2-deoxy-scyllo-inosose (DOI) in cyanobacterium Synechococcus elongatus strain PCC 7942, production of 400 mg/l of DOI without using an external carbon source, method overview Niallia circulans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.124 D-glucose 6-phosphate Niallia circulans
-
 2-deoxy-L-scyllo-inosose + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.124 Niallia circulans Q9S5E2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.124 D-glucose 6-phosphate
-
 Niallia circulans 2-deoxy-L-scyllo-inosose + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.124 btrC
-
 Niallia circulans
4.2.3.124 DOI synthase
-
 Niallia circulans
4.2.3.124 DOIS
-
 Niallia circulans

General Information

EC Number General Information Comment Organism
4.2.3.124 physiological function DOI synthase (DOIS) is responsible for the formation of DOI from D-glucose-6-phosphate in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics such as neomycin and butirosin Niallia circulans