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Literature summary extracted from

  • De Luca, V.; Del Prete, S.; Carginale, V.; Vullo, D.; Supuran, C.T.; Capasso, C.
    Cloning, characterization and anion inhibition studies of a gamma-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune (2015), Bioorg. Med. Chem. Lett., 25, 4970-4975 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.1 DNA and amino acid sequence comparisons, phylogenetic tree of gamma-CAs Nostoc commune

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 acetazolamide
-
 Nostoc commune
4.2.1.1 B4O72-
-
 Nostoc commune
4.2.1.1 Br-
-
 Nostoc commune
4.2.1.1 CF3SO3-
-
 Nostoc commune
4.2.1.1 Cl-
-
 Nostoc commune
4.2.1.1 CN-
-
 Nostoc commune
4.2.1.1 CNO-
-
 Nostoc commune
4.2.1.1 CO32-
-
 Nostoc commune
4.2.1.1 CS32-
-
 Nostoc commune
4.2.1.1 diethyldithiocarbamate
-
 Nostoc commune
4.2.1.1 Et2NCS2-
-
 Nostoc commune
4.2.1.1 FSO3-
-
 Nostoc commune
4.2.1.1 H2NSO2NH2
-
 Nostoc commune
4.2.1.1 H2NSO3H
-
 Nostoc commune
4.2.1.1 HCO3-
-
 Nostoc commune
4.2.1.1 HS-
-
 Nostoc commune
4.2.1.1 HSO3-
-
 Nostoc commune
4.2.1.1 I-
-
 Nostoc commune
4.2.1.1 additional information fluoride, sulfate, perchlorate and tetrafluoroborate do not inhibit appreciably NcoCA, whereas the other halides, pseudohalides, bicarbonate, nitrate, nitrite and many complex inorganic anions cause inhibition in the millimolar range Nostoc commune
4.2.1.1 N3-
-
 Nostoc commune
4.2.1.1 NH(SO3)22-
-
 Nostoc commune
4.2.1.1 NO2-
-
 Nostoc commune
4.2.1.1 NO3-
-
 Nostoc commune
4.2.1.1 P2O74-
-
 Nostoc commune
4.2.1.1 PF6-
-
 Nostoc commune
4.2.1.1 Ph-AsO3H2
-
 Nostoc commune
4.2.1.1 Ph-B(OH)2
-
 Nostoc commune
4.2.1.1 ReO4-
-
 Nostoc commune
4.2.1.1 RuO4-
-
 Nostoc commune
4.2.1.1 S2O82-
-
 Nostoc commune
4.2.1.1 SCN-
-
 Nostoc commune
4.2.1.1 SeCN-
-
 Nostoc commune
4.2.1.1 SeO42-
-
 Nostoc commune
4.2.1.1 SnO32-
-
 Nostoc commune
4.2.1.1 TeO42-
-
 Nostoc commune
4.2.1.1 V2O74-
-
 Nostoc commune

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.1 carboxysome
-
 Nostoc commune 31470
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.1 Zn2+ metal ion ligands are His81, Hist117 and His122 Nostoc commune

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.1 CO2 + H2O Nostoc commune
-
 H2CO3
-
 r
4.2.1.1 additional information Nostoc commune the enzyme has significant catalytic activity for the physiologic reaction, CO2 hydration to bicarbonate and protons ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Nostoc commune
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
 Nostoc commune H2CO3
-
 r
4.2.1.1 H2CO3
-
 Nostoc commune CO2 + H2O
-
 r
4.2.1.1 additional information the enzyme has significant catalytic activity for the physiologic reaction, CO2 hydration to bicarbonate and protons Nostoc commune ?
-
 ?
4.2.1.1 additional information the enzyme is highly active in the CO2 hydration reaction Nostoc commune ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 gamma-CA
-
 Nostoc commune
4.2.1.1 gamma-carbonic anhydrase
-
 Nostoc commune
4.2.1.1 NcoCA
-
 Nostoc commune

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.1 950000
-
 CO2 pH 7.5, 20°C Nostoc commune

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.07
-
 Ph-B(OH)2 pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 0.0758
-
 acetazolamide pH 7.5, 20°C Nostoc commune
4.2.1.1 0.081
-
 H2NSO2NH2 pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 0.084
-
 Ph-AsO3H2 pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 0.09
-
 H2NSO3H pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 0.8
-
 diethyldithiocarbamate pH 7.5, 20°C Nostoc commune
4.2.1.1 0.8
-
 Et2NCS2- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 2.4
-
 CO32- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 4.5
-
 HCO3- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 5.4
-
 SnO32- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 6
-
 CNO- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 6.4
-
 B4O72- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 6.7
-
 CN- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 6.9
-
 NH(SO3)22- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 7.3
-
 CF3SO3- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 7.4
-
 PF6- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 7.6
-
 V2O74- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 7.6
-
 RuO4- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 7.7
-
 TeO42- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 8
-
 SeCN- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 8.1
-
 SCN- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 8.5
-
 SeO42- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 8.7
-
 Cl- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 8.8
-
 NO2- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 8.8
-
 ReO4- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 8.9
-
 I- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 8.9
-
 CS32- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 9.1
-
 P2O74- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 9.3
-
 Br- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 9.5
-
 FSO3- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 9.5
-
 S2O82- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 14.9
-
 HSO3- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 20.4
-
 HS- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 27.6
-
 NO3- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune
4.2.1.1 30.5
-
 N3- pH 7.5, 20°C, inhibition of CO2 hydration activity Nostoc commune

General Information

EC Number General Information Comment Organism
4.2.1.1 evolution phylogenetic tree of gamma-CAs Nostoc commune
4.2.1.1 physiological function gamma-CAs are present in carboxysomes, being involved in photosynthesis Nostoc commune

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.2.1.1 83000
-
 CO2 pH 7.5, 20°C Nostoc commune