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Literature summary extracted from

  • Wang, P.; Jiang, L.; Cao, Y.; Zhang, X.; Chen, B.; Zhang, S.; Huang, K.; Ye, D.; Zhou, L.
    Xanthone derivatives as phosphoglycerate mutase 1 inhibitors Design, synthesis, and biological evaluation (2018), Bioorg. Med. Chem., 26, 1961-1970 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.2.11 1-phenyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)methanesulfonamide
-
 Homo sapiens
5.4.2.11 2,5-bis(trifluoromethyl)-N-(1,2,8-trihydroxy-9-oxo-9Hxanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 3-(trifluoromethoxy)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 3-cyano-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 3-cyano-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzene-1-sulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 4-(piperidin-1-yl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 4-(pyrrolidin-1-yl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 4-(tert-butyl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 4-(tert-butyl)-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 4-(trifluoromethyl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 4-bromo-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 4-bromo-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 4-chloro-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 4-chloro-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 4-cyano-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 4-cyano-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzene-1-sulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 4-cyclohexyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 4-cyclohexyl-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 4-fluoro-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 4-fluoro-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 4-iodo-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 4-methyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 Alizarin Red S
-
 Homo sapiens
5.4.2.11 epigallocatechin gallate
-
 Homo sapiens
5.4.2.11 MJE3
-
 Homo sapiens
5.4.2.11 N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)-[1,10-biphenyl]-4-sulfonamide
-
 Homo sapiens
5.4.2.11 N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
 Homo sapiens
5.4.2.11 N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
-
 Homo sapiens
5.4.2.11 N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-2-sulfonamide
-
 Homo sapiens
5.4.2.11 N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-1-phenylmethanesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-2,5-bis(trifluoromethyl)benzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-3-(trifluoromethoxy)benzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(piperidin-1-yl)benzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(pyrrolidin-1-yl)benzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(trifluoromethyl)benzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-iodobenzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-methylbenzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-[1,10-biphenyl]-4-sulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)naphthalene-2-sulfonamide less than 10% inhibition at 0.02 mM Homo sapiens
5.4.2.11 PGMI-004A
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.2.11 2-phospho-D-glycerate Homo sapiens
-
 3-phospho-D-glycerate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.4.2.11 Homo sapiens P18669
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.2.11 H-1299 cell
-
 Homo sapiens
-
5.4.2.11 MCF-7 cell
-
 Homo sapiens
-
5.4.2.11 PANC-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.2.11 2-phospho-D-glycerate
-
 Homo sapiens 3-phospho-D-glycerate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.4.2.11 PGAM1
-
 Homo sapiens
5.4.2.11 phosphoglycerate mutase 1
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.4.2.11 0.00049
-
 at pH 8.0 and 25°C Homo sapiens epigallocatechin gallate
5.4.2.11 0.0005
-
 at pH 8.0 and 25°C Homo sapiens 4-cyclohexyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.001
-
 at pH 8.0 and 25°C Homo sapiens 4-(piperidin-1-yl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0012
-
 at pH 8.0 and 25°C Homo sapiens N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)-[1,10-biphenyl]-4-sulfonamide
5.4.2.11 0.0016
-
 at pH 8.0 and 25°C Homo sapiens N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-2-sulfonamide
5.4.2.11 0.0017
-
 at pH 8.0 and 25°C Homo sapiens N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
5.4.2.11 0.0019
-
 at pH 8.0 and 25°C Homo sapiens 1-phenyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)methanesulfonamide
5.4.2.11 0.0019
-
 at pH 8.0 and 25°C Homo sapiens 4-iodo-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0021
-
 at pH 8.0 and 25°C Homo sapiens 3-cyano-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0026
-
 at pH 8.0 and 25°C Homo sapiens 4-(tert-butyl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0027
-
 at pH 8.0 and 25°C Homo sapiens 4-(pyrrolidin-1-yl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0028
-
 at pH 8.0 and 25°C Homo sapiens N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0029
-
 at pH 8.0 and 25°C Homo sapiens 4-bromo-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0035
-
 at pH 8.0 and 25°C Homo sapiens 4-(trifluoromethyl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0036
-
 at pH 8.0 and 25°C Homo sapiens 4-chloro-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0042
-
 at pH 8.0 and 25°C Homo sapiens 4-cyano-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0055
-
 at pH 8.0 and 25°C Homo sapiens 4-fluoro-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0058
-
 at pH 8.0 and 25°C Homo sapiens 3-(trifluoromethoxy)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0063
-
 at pH 8.0 and 25°C Homo sapiens 2,5-bis(trifluoromethyl)-N-(1,2,8-trihydroxy-9-oxo-9Hxanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0072
-
 at pH 8.0 and 25°C Homo sapiens 4-methyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.013
-
 at pH 8.0 and 25°C Homo sapiens PGMI-004A
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens 3-cyano-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzene-1-sulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens 4-(tert-butyl)-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens 4-bromo-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens 4-chloro-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens 4-cyano-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzene-1-sulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens 4-fluoro-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-1-phenylmethanesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-2,5-bis(trifluoromethyl)benzenesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-3-(trifluoromethoxy)benzenesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(piperidin-1-yl)benzenesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(pyrrolidin-1-yl)benzenesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(trifluoromethyl)benzenesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-iodobenzenesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-methylbenzenesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-[1,10-biphenyl]-4-sulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)naphthalene-2-sulfonamide
5.4.2.11 0.02
-
 IC50 value far above 0.02 mM, at pH 8.0 and 25°C Homo sapiens 4-cyclohexyl-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide