BRENDA - Enzyme Database

Xanthone derivatives as phosphoglycerate mutase 1 inhibitors Design, synthesis, and biological evaluation

Wang, P.; Jiang, L.; Cao, Y.; Zhang, X.; Chen, B.; Zhang, S.; Huang, K.; Ye, D.; Zhou, L.; Bioorg. Med. Chem. 26, 1961-1970 (2018)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.4.2.11
1-phenyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)methanesulfonamide
-
Homo sapiens
5.4.2.11
2,5-bis(trifluoromethyl)-N-(1,2,8-trihydroxy-9-oxo-9Hxanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
3-(trifluoromethoxy)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
3-cyano-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
3-cyano-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzene-1-sulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-(piperidin-1-yl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-(pyrrolidin-1-yl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-(tert-butyl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-(tert-butyl)-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-(trifluoromethyl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-bromo-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-bromo-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-chloro-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-chloro-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-cyano-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-cyano-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzene-1-sulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-cyclohexyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-cyclohexyl-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-fluoro-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-fluoro-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-iodo-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-methyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
Alizarin Red S
-
Homo sapiens
5.4.2.11
epigallocatechin gallate
-
Homo sapiens
5.4.2.11
MJE3
-
Homo sapiens
5.4.2.11
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)-[1,10-biphenyl]-4-sulfonamide
-
Homo sapiens
5.4.2.11
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
-
Homo sapiens
5.4.2.11
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-2-sulfonamide
-
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-1-phenylmethanesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-2,5-bis(trifluoromethyl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-3-(trifluoromethoxy)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(piperidin-1-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(pyrrolidin-1-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(trifluoromethyl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-iodobenzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-methylbenzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-[1,10-biphenyl]-4-sulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)naphthalene-2-sulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
PGMI-004A
-
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.4.2.11
2-phospho-D-glycerate
Homo sapiens
-
3-phospho-D-glycerate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.4.2.11
Homo sapiens
P18669
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.4.2.11
H-1299 cell
-
Homo sapiens
-
5.4.2.11
MCF-7 cell
-
Homo sapiens
-
5.4.2.11
PANC-1 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.4.2.11
2-phospho-D-glycerate
-
747262
Homo sapiens
3-phospho-D-glycerate
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
5.4.2.11
0.00049
-
at pH 8.0 and 25°C
Homo sapiens
epigallocatechin gallate
5.4.2.11
0.0005
-
at pH 8.0 and 25°C
Homo sapiens
4-cyclohexyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.001
-
at pH 8.0 and 25°C
Homo sapiens
4-(piperidin-1-yl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0012
-
at pH 8.0 and 25°C
Homo sapiens
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)-[1,10-biphenyl]-4-sulfonamide
5.4.2.11
0.0016
-
at pH 8.0 and 25°C
Homo sapiens
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-2-sulfonamide
5.4.2.11
0.0017
-
at pH 8.0 and 25°C
Homo sapiens
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
5.4.2.11
0.0019
-
at pH 8.0 and 25°C
Homo sapiens
1-phenyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)methanesulfonamide
5.4.2.11
0.0019
-
at pH 8.0 and 25°C
Homo sapiens
4-iodo-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0021
-
at pH 8.0 and 25°C
Homo sapiens
3-cyano-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0026
-
at pH 8.0 and 25°C
Homo sapiens
4-(tert-butyl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0027
-
at pH 8.0 and 25°C
Homo sapiens
4-(pyrrolidin-1-yl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0028
-
at pH 8.0 and 25°C
Homo sapiens
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0029
-
at pH 8.0 and 25°C
Homo sapiens
4-bromo-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0035
-
at pH 8.0 and 25°C
Homo sapiens
4-(trifluoromethyl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0036
-
at pH 8.0 and 25°C
Homo sapiens
4-chloro-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0042
-
at pH 8.0 and 25°C
Homo sapiens
4-cyano-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0055
-
at pH 8.0 and 25°C
Homo sapiens
4-fluoro-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0058
-
at pH 8.0 and 25°C
Homo sapiens
3-(trifluoromethoxy)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0063
-
at pH 8.0 and 25°C
Homo sapiens
2,5-bis(trifluoromethyl)-N-(1,2,8-trihydroxy-9-oxo-9Hxanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0072
-
at pH 8.0 and 25°C
Homo sapiens
4-methyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.013
-
at pH 8.0 and 25°C
Homo sapiens
PGMI-004A
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
3-cyano-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzene-1-sulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
4-bromo-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
4-chloro-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
4-cyano-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzene-1-sulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
4-cyclohexyl-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
4-fluoro-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
4-(tert-butyl)-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-[1,10-biphenyl]-4-sulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-1-phenylmethanesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-2,5-bis(trifluoromethyl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-3-(trifluoromethoxy)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-iodobenzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-methylbenzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(piperidin-1-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(pyrrolidin-1-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(trifluoromethyl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)naphthalene-2-sulfonamide
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
5.4.2.11
0.00049
-
at pH 8.0 and 25°C
Homo sapiens
epigallocatechin gallate
5.4.2.11
0.0005
-
at pH 8.0 and 25°C
Homo sapiens
4-cyclohexyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.001
-
at pH 8.0 and 25°C
Homo sapiens
4-(piperidin-1-yl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0012
-
at pH 8.0 and 25°C
Homo sapiens
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)-[1,10-biphenyl]-4-sulfonamide
5.4.2.11
0.0016
-
at pH 8.0 and 25°C
Homo sapiens
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-2-sulfonamide
5.4.2.11
0.0017
-
at pH 8.0 and 25°C
Homo sapiens
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
5.4.2.11
0.0019
-
at pH 8.0 and 25°C
Homo sapiens
1-phenyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)methanesulfonamide
5.4.2.11
0.0019
-
at pH 8.0 and 25°C
Homo sapiens
4-iodo-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0021
-
at pH 8.0 and 25°C
Homo sapiens
3-cyano-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0026
-
at pH 8.0 and 25°C
Homo sapiens
4-(tert-butyl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0027
-
at pH 8.0 and 25°C
Homo sapiens
4-(pyrrolidin-1-yl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0028
-
at pH 8.0 and 25°C
Homo sapiens
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0029
-
at pH 8.0 and 25°C
Homo sapiens
4-bromo-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0035
-
at pH 8.0 and 25°C
Homo sapiens
4-(trifluoromethyl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0036
-
at pH 8.0 and 25°C
Homo sapiens
4-chloro-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0042
-
at pH 8.0 and 25°C
Homo sapiens
4-cyano-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0055
-
at pH 8.0 and 25°C
Homo sapiens
4-fluoro-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0058
-
at pH 8.0 and 25°C
Homo sapiens
3-(trifluoromethoxy)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0063
-
at pH 8.0 and 25°C
Homo sapiens
2,5-bis(trifluoromethyl)-N-(1,2,8-trihydroxy-9-oxo-9Hxanthen-3-yl)benzenesulfonamide
5.4.2.11
0.0072
-
at pH 8.0 and 25°C
Homo sapiens
4-methyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.013
-
at pH 8.0 and 25°C
Homo sapiens
PGMI-004A
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
3-cyano-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzene-1-sulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
4-bromo-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
4-chloro-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
4-cyano-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzene-1-sulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
4-cyclohexyl-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
4-fluoro-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
4-(tert-butyl)-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-[1,10-biphenyl]-4-sulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-1-phenylmethanesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-2,5-bis(trifluoromethyl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-3-(trifluoromethoxy)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-iodobenzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-methylbenzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(piperidin-1-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(pyrrolidin-1-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(trifluoromethyl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
5.4.2.11
0.02
-
IC50 value far above 0.02 mM, at pH 8.0 and 25°C
Homo sapiens
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)naphthalene-2-sulfonamide
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.4.2.11
1-phenyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)methanesulfonamide
-
Homo sapiens
5.4.2.11
2,5-bis(trifluoromethyl)-N-(1,2,8-trihydroxy-9-oxo-9Hxanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
3-(trifluoromethoxy)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
3-cyano-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
3-cyano-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzene-1-sulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-(piperidin-1-yl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-(pyrrolidin-1-yl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-(tert-butyl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-(tert-butyl)-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-(trifluoromethyl)-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-bromo-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-bromo-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-chloro-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-chloro-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-cyano-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-cyano-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzene-1-sulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-cyclohexyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-cyclohexyl-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-fluoro-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-fluoro-N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
4-iodo-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
4-methyl-N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
Alizarin Red S
-
Homo sapiens
5.4.2.11
epigallocatechin gallate
-
Homo sapiens
5.4.2.11
MJE3
-
Homo sapiens
5.4.2.11
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)-[1,10-biphenyl]-4-sulfonamide
-
Homo sapiens
5.4.2.11
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
-
Homo sapiens
5.4.2.11
N-(1,2,8-trihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-2-sulfonamide
-
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-1-phenylmethanesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-2,5-bis(trifluoromethyl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-3-(trifluoromethoxy)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(piperidin-1-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(pyrrolidin-1-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-(trifluoromethyl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-iodobenzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-4-methylbenzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)-[1,10-biphenyl]-4-sulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
N-(1-hydroxy-2,8-dimethoxy-9-oxo-9H-xanthen-3-yl)naphthalene-2-sulfonamide
less than 10% inhibition at 0.02 mM
Homo sapiens
5.4.2.11
PGMI-004A
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.4.2.11
2-phospho-D-glycerate
Homo sapiens
-
3-phospho-D-glycerate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.4.2.11
H-1299 cell
-
Homo sapiens
-
5.4.2.11
MCF-7 cell
-
Homo sapiens
-
5.4.2.11
PANC-1 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.4.2.11
2-phospho-D-glycerate
-
747262
Homo sapiens
3-phospho-D-glycerate
-
-
-
?