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Literature summary extracted from

  • Joshi, S.; Dixit, S.; Basha, J.; Kulkarni, V.; Aminabhavi, T.; Nadagouda, M.; Lherbet, C.
    Pharmacophore mapping, molecular docking, chemical synthesis of some novel pyrrolyl benzamide derivatives and evaluation of their inhibitory activity against enoyl-ACP reductase (InhA) and Mycobacterium tuberculosis (2018), Bioorg. Chem., 81, 440-453 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.118 expression of InHA-6xHis protein in Escherichia coli (BL21) Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.1.118 molecular docking studies are performed on the crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) complexed with 1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.118 N-(2,3-dichlorophenyl)-4-(1H-pyrrol-1-yl)benzamide anti-tuberculosis activity Mycobacterium tuberculosis
1.3.1.118 N-(2-aminophenyl)-4-(1H-pyrrol-1-yl)benzamide anti-tuberculosis activity Mycobacterium tuberculosis
1.3.1.118 N-(2-nitrophenyl)-4-(1H-pyrrol-1-yl)benzamide anti-tuberculosis activity Mycobacterium tuberculosis
1.3.1.118 N-(3-fluorophenyl)-4-(1H-pyrrol-1-yl)benzamide anti-tuberculosis activity Mycobacterium tuberculosis
1.3.1.118 N-(4-chlorophenyl)-4-(1H-pyrrol-1-yl)benzamide anti-tuberculosis activity Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.118 Mycobacterium tuberculosis P9WGR1
-
-
1.3.1.118 Mycobacterium tuberculosis H37Rv P9WGR1
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.118
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.118 trans-2-dodecenoyl-CoA + NADH + H+
-
 Mycobacterium tuberculosis dodecanoyl-CoA + NAD+
-
 ?
1.3.1.118 trans-2-dodecenoyl-CoA + NADH + H+
-
 Mycobacterium tuberculosis H37Rv dodecanoyl-CoA + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.118 enoyl-ACP reductase
-
 Mycobacterium tuberculosis
1.3.1.118 InhA
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
1.3.1.118 metabolism the enzyme is involved in type II fatty acid biosynthetic pathway Mycobacterium tuberculosis