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Literature summary extracted from

  • Keppler, D.; Leier, I.; Jedlitschky, G.
    Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2 (1997), Biol. Chem., 378, 787-791 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.3 canalicular membrane
-
Homo sapiens
-
-
7.6.2.3 plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1] Homo sapiens
-
ADP + phosphate + glutathione-S-conjugate[side 2]
-
?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.3 Homo sapiens Q92887
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.3 erythrocyte
-
Homo sapiens
-
7.6.2.3 hepatocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.3 ATP + H2O + glutathione disulfide[side 1]
-
Homo sapiens ADP + phosphate + glutathione disulfide[side 2]
-
?
7.6.2.3 ATP + H2O + glutathione-S-conjugate[side 1]
-
Homo sapiens ADP + phosphate + glutathione-S-conjugate[side 2]
-
?
7.6.2.3 ATP + H2O + S-(17beta-glucuronosyl estradiol)glutathione[side 1]
-
Homo sapiens ADP + phosphate + S-(17beta-glucuronosyl estradiol)glutathione[side 2]
-
?
7.6.2.3 ATP + H2O + S-(6alpha-glucuronosyl hyodeoxycholate)glutathione[side 1]
-
Homo sapiens ADP + phosphate + S-(6alpha-glucuronosyl hyodeoxycholate)glutathione[side 2]
-
?
7.6.2.3 ATP + H2O + S-(bilirubin glucuronide)glutathione[side 1]
-
Homo sapiens ADP + phosphate + S-(bilirubin glucuronide)glutathione[side 2]
-
?
7.6.2.3 ATP + H2O + S-(C4-glutathione)glutathione[side 1]
-
Homo sapiens ADP + phosphate + S-(C4-glutathione)glutathione[side 2]
-
?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.3 canalicular MRP
-
Homo sapiens
7.6.2.3 canalicular multispecific organic anion transporter
-
Homo sapiens
7.6.2.3 cMOAT
-
Homo sapiens
7.6.2.3 cMRP
-
Homo sapiens
7.6.2.3 MRP1
-
Homo sapiens
7.6.2.3 MRP2
-
Homo sapiens
7.6.2.3 multidrug resistance-associated protein 1
-
Homo sapiens

General Information

EC Number General Information Comment Organism
7.6.2.3 physiological function the enzyme is associated with multiple drug resistance of malignant tumors because of their capacity to pump drug conjugates and drug complexes across the plasma membrane into the extracellular space Homo sapiens