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Literature summary extracted from

  • Warui, D.M.; Pandelia, M.E.; Rajakovich, L.J.; Krebs, C.; Bollinger, J.M.; Booker, S.J.
    Efficient delivery of long-chain fatty aldehydes from the Nostoc punctiforme acyl-acyl carrier protein reductase to its cognate aldehyde-deformylating oxygenase (2015), Biochemistry, 54, 1006-1015 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.99.5 a long-chain aldehyde + O2 + 2 NADPH + 2 H+ Nostoc punctiforme
-
 an alkane + formate + H2O + 2 NADP+
-
 ?
4.1.99.5 a long-chain aldehyde + O2 + 2 NADPH + 2 H+ Nostoc punctiforme ATCC 29133 / PCC 73102
-
 an alkane + formate + H2O + 2 NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.5 Nostoc punctiforme B2J1M1
-
-
4.1.99.5 Nostoc punctiforme ATCC 29133 / PCC 73102 B2J1M1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.99.5 a long-chain aldehyde + O2 + 2 NADPH + 2 H+
-
 Nostoc punctiforme an alkane + formate + H2O + 2 NADP+
-
 ?
4.1.99.5 a long-chain aldehyde + O2 + 2 NADPH + 2 H+
-
 Nostoc punctiforme ATCC 29133 / PCC 73102 an alkane + formate + H2O + 2 NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.99.5 ADO
-
 Nostoc punctiforme
4.1.99.5 aldehyde-deformylating oxygenase
-
 Nostoc punctiforme

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.99.5 NADPH
-
 Nostoc punctiforme

General Information

EC Number General Information Comment Organism
4.1.99.5 metabolism efficient delivery of long-chain fatty aldehydes from the Nostoc punctiforme acyl-acyl carrier protein reductase to its cognate aldehyde-deformylating oxygenase in a two-step pathway consisting of an acyl-acyl carrier protein (ACP) reductase (AAR) and an aldehyde-deformylating oxygenase (ADO) allowing various cyanobacteria to convert long-chain fatty acids into hydrocarbons. When the aldehyde substrate is supplied to ADO by AAR, efficient in vitro turnover is observed in the absence of solubilizing agents, even with insoluble substrates like octadec(a/e)nal, overview. AAR and ADO form a tight isolable complex with a Kd of 0.003 mM. The interaction between AAR and ADO facilitates either direct transfer of the aldehyde product of AAR to ADO or formation of the aldehyde product in a microenvironment allowing for its efficient uptake by ADO Nostoc punctiforme
4.1.99.5 physiological function aldehyde-deformylating oxygenase (ADO) is an important enzyme involved in the biosynthetic pathway of fatty alk(a/e)nes in cyanobacteria. ADO transforms the fatty aldehyde to a Cn-1 hydrocarbon and C1-derived formate Nostoc punctiforme