Literature summary extracted from

Luebker, C.; Urbauer, R.; Moskovitz, J.; Dove, S.; Weisemann, J.; Fedorova, M.; Urbauer, J.; Seifert, R.
Membranous adenylyl cyclase 1 activation is regulated by oxidation of N- and C-terminal methionine residues in calmodulin (2015), Biochem. Pharmacol., 93, 196-209 .

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
4.6.1.1	Calmodulin	calmodulin activation of isoform Adcy1 can be regulated by selctive oxidation of the C-terminal Met residues in calmodulin, and by two N-terminal Met residues, M36 and M51. CaM with all Met residues oxidized is unable to activate the enzyme	Bos taurus

Application

EC Number	Application	Comment	Organism
4.6.1.1	medicine	isoform Adcy1 catalytic activity can be delicately adjusted by mediating calmodulin activation of Adcy1 by reversible Met oxidation in calmodulin	Bos taurus

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.6.1.1	Bos taurus	P19754	isoform Adcy1	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)