Literature summary extracted from

Hidaka, M.; Kosaka, K.; Tsushima, S.; Uchida, C.; Takahashi, K.; Takahashi, N.; Tsubuki, M.; Hara, Y.; Uchida, T.
Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1 (2018), Biochem. Biophys. Res. Commun., 499, 681-687 .

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
5.2.1.8	expression in Escherichia coli	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.2.1.8	(E)-6-phenylhexyl 3-(3,4-dihydroxyphenyl)acrylate	20 micorM, 15% residual activity	Homo sapiens
5.2.1.8	epigallocatechin-3-gallate	10 microM, 55% residual activity	Homo sapiens
5.2.1.8	additional information	food polyphenols carrying a galloyl group show significant inhibition	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.2.1.8	Homo sapiens	Q13526	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.2.1.8	N-succinyl-Ala-Glu-(cis)-Pro-Phe-p-nitroanilide	-	Homo sapiens	N-succinyl-Ala-Glu-(trans)-Pro-Phe-p-nitroanilide	-	?

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Release 2023.1 (January 2023)