Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Falcao, V.C.; Villela, A.D.; Rodrigues-Junior, V.S.; Pissinate, K.; Eichler, P.; Pinto, A.F.; Basso, L.A.; Santos, D.S.; Bizarro, C.V.
    Validation of Mycobacterium tuberculosis dihydroneopterin aldolase as a molecular target for anti-tuberculosis drug development (2017), Biochem. Biophys. Res. Commun., 485, 814-819 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.2.25 expressed in Escherichia coli BL21(DE3) cells Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
4.1.2.25 K99A inactive Mycobacterium tuberculosis
4.1.2.25 Y54F inactive Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.25 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde Mycobacterium tuberculosis
-
7,8-dihydroneopterin + 7,8-dihydromonapterin
-
r
4.1.2.25 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde Mycobacterium tuberculosis H37Rv
-
7,8-dihydroneopterin + 7,8-dihydromonapterin
-
r
4.1.2.25 7,8-dihydroneopterin Mycobacterium tuberculosis
-
6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde
-
r
4.1.2.25 7,8-dihydroneopterin Mycobacterium tuberculosis H37Rv
-
6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde
-
r

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.25 Mycobacterium tuberculosis P9WNG5
-
-
4.1.2.25 Mycobacterium tuberculosis H37Rv P9WNG5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.2.25
-
Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.25 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
-
Mycobacterium tuberculosis 7,8-dihydroneopterin + 7,8-dihydromonapterin
-
r
4.1.2.25 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
-
Mycobacterium tuberculosis H37Rv 7,8-dihydroneopterin + 7,8-dihydromonapterin
-
r
4.1.2.25 7,8-dihydroneopterin
-
Mycobacterium tuberculosis 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde
-
r
4.1.2.25 7,8-dihydroneopterin
-
Mycobacterium tuberculosis H37Rv 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde
-
r

Subunits

EC Number Subunits Comment Organism
4.1.2.25 ? x * 14412, calculated from amino acid sequence Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
4.1.2.25 dihydroneopterin aldolase/epimerase
-
Mycobacterium tuberculosis
4.1.2.25 FolB
-
Mycobacterium tuberculosis
4.1.2.25 Rv3607c
-
Mycobacterium tuberculosis