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Literature summary extracted from

  • Wagner, M.; Shen, L.; Albersmeier, A.; van der Kolk, N.; Kim, S.; Cha, J.; Brไsen, C.; Kalinowski, J.; Siebers, B.; Albers, S.
    Sulfolobus acidocaldarius transports pentoses via a carbohydrate uptake transporter 2 (CUT2)-type ABC transporter and metabolizes them through the aldolase-independent Weimberg pathway (2018), Appl. Environ. Microbiol., 84, pii: e01273-17 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.141 additional information the deletion mutant DELTAKDXD/KDAD of the 2-keto-3-deoxyarabinoate/xylonate dehydratase is no longer able to catabolize D-xylose or L-arabinose, suggesting the absence of the aldolase-dependent branch in Sulfolobus acidocaldarius. In the DELTAKDXD/KDAD mutant, no KDXD/KDAD activity is detected on the four different carbon and energy sources, confirming the absence of an alternative pathway/enzyme for KDX/KDA conversion under these conditions in Sulfolobus acidocaldarius strain MW001 Sulfolobus acidocaldarius

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.141 2-dehydro-3-deoxy-D-arabinonate Sulfolobus acidocaldarius
-
 2,5-dioxopentanoate + H2O
-
 ?
4.2.1.141 2-dehydro-3-deoxy-D-arabinonate Sulfolobus acidocaldarius ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770
-
 2,5-dioxopentanoate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.141 Sulfolobus acidocaldarius Q4J7I6
-
-
4.2.1.141 Sulfolobus acidocaldarius ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770 Q4J7I6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.141 2-dehydro-3-deoxy-D-arabinonate
-
 Sulfolobus acidocaldarius 2,5-dioxopentanoate + H2O
-
 ?
4.2.1.141 2-dehydro-3-deoxy-D-arabinonate
-
 Sulfolobus acidocaldarius ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770 2,5-dioxopentanoate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.141 2-keto-3-deoxyarabinoate/xylonate dehydratase
-
 Sulfolobus acidocaldarius
4.2.1.141 KdaD
-
 Sulfolobus acidocaldarius
4.2.1.141 KDXD
-
 Sulfolobus acidocaldarius
4.2.1.141 KDXD/KDAD
-
 Sulfolobus acidocaldarius
4.2.1.141 saci_1939
-
 Sulfolobus acidocaldarius

Expression

EC Number Organism Comment Expression
4.2.1.141 Sulfolobus acidocaldarius the KDXD/KDAD activity in the wild-type MW001 and DELTAKGSADH mutant strains and the DELTAABC-SBP strain is induced to 35 mU/mg when D-xylose or L-arabinose is used as the growth substrate. In the absence of these sugars, i.e., on N-Z-amine alone and on N-Z-amine plus dextrin as the carbon and energy source, only negligible KDXD/KDAD activity is observed up

General Information

EC Number General Information Comment Organism
4.2.1.141 malfunction the 2-ketoglutarate semialdehyde dehydrogenase (KGSADH, Saci_1938) seems not to be essential for growth on pentoses. The deletion mutant of the 2-keto-3-deoxyarabinoate/xylonate dehydratase (KDXD/KDAD) is no longer able to catabolize D-xylose or L-arabinose, suggesting the absence of the aldolase-dependent branch in Sulfolobus acidocaldarius Sulfolobus acidocaldarius