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Literature summary extracted from

  • Pulaganti, M.; Banaganapalli, B.; Mulakayala, C.; Chitta, S.; Anuradha, C.
    Molecular modeling and docking studies of O-succinylbenzoate synthase of M. tuberculosis - a potential target for antituberculosis drug design (2014), Appl. Biochem. Biotechnol., 172, 1407-1432 .
    View publication on PubMed

Application

EC Number Application Comment Organism
4.2.1.113 drug development the enzyme is one of the major potential drug targets for Mycobacterium tuberculosis Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.113 additional information ligand docking interactions analysis, potential of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate substrate (SHCHC) derivatives as competitive enzyme inhibitors, overview Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.113 (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate Mycobacterium tuberculosis
-
 2-succinylbenzoate + H2O
-
 ?
4.2.1.113 (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate Mycobacterium tuberculosis ATCC 25618 / H37Rv
-
 2-succinylbenzoate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.113 Mycobacterium tuberculosis P9WJP3
-
-
4.2.1.113 Mycobacterium tuberculosis ATCC 25618 / H37Rv P9WJP3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.113 (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
-
 Mycobacterium tuberculosis 2-succinylbenzoate + H2O
-
 ?
4.2.1.113 (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate the enzyme converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate via an elimination of water. The reaction likely proceeds by a mechanism similar to those employed by other members of the enolase superfamily with initial abstraction of the R-proton of the carboxylic acid and stabilization of the resulting enolic intermediate Mycobacterium tuberculosis 2-succinylbenzoate + H2O
-
 ?
4.2.1.113 (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
-
 Mycobacterium tuberculosis ATCC 25618 / H37Rv 2-succinylbenzoate + H2O
-
 ?
4.2.1.113 (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate the enzyme converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate via an elimination of water. The reaction likely proceeds by a mechanism similar to those employed by other members of the enolase superfamily with initial abstraction of the R-proton of the carboxylic acid and stabilization of the resulting enolic intermediate Mycobacterium tuberculosis ATCC 25618 / H37Rv 2-succinylbenzoate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.113 Mtb-OSBS
-
 Mycobacterium tuberculosis
4.2.1.113 OSBS
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
4.2.1.113 metabolism O-succinylbenzoate synthase plays a major role in the shikimate pathway Mycobacterium tuberculosis
4.2.1.113 additional information molecular modeling and docking study of O-succinylbenzoate synthase of Mycobacterium tuberculosis, overview. A three-dimensional structure model of Mtb-OSBS is built using structure coordinates of Thermobifida fusca. Residues Lys108, Asn140, Asp138, Lys110, Glu189, Ser236, Asp188, Arg27, Tyr52, and Ser237 are highly conserved and may play a vital role as active residues Mycobacterium tuberculosis
4.2.1.113 physiological function O-succinylbenzoate synthase is an important enzyme in the biosynthesis of menaquinone, ubiquinone, and terpenoid quinone in Mycobacterium tuberculosis Mycobacterium tuberculosis