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Literature summary extracted from

  • Ceccom, J.; Loukh, N.; Lauwers-Cances, V.; Touriol, C.; Nicaise, Y.; Gentil, C.; Uro-Coste, E.; Pitson, S.; Maurage, C.A.; Duyckaerts, C.; Cuvillier, O.; Delisle, M.B.
    Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimers disease (2014), Acta Neuropathol. Commun., 2, 12 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.27 sphinganine 1-phosphate Homo sapiens
-
 phosphoethanolamine + palmitaldehyde
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.27 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.2.27 brain cortex cell line
-
 Homo sapiens
-
4.1.2.27 hippocampus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.27 sphinganine 1-phosphate
-
 Homo sapiens phosphoethanolamine + palmitaldehyde
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.2.27 ? x * 75000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
4.1.2.27 sphingosine 1-phosphate lyase
-
 Homo sapiens
4.1.2.27 SPL
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
4.1.2.27 Homo sapiens enzyme expression is increased in brains of patients with Alzheimer's disease up