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Literature summary extracted from

  • Chen, X.; Zhang, C.; Zou, R.; Stephanopoulos, G.; Too, H.P.
    In vitro metabolic engineering of amorpha-4,11-diene biosynthesis at enhanced rate and specific yield of production (2017), ACS Synth. Biol., 6, 1691-1700 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.3.24 ADP about 20% inhibition at 15 mM Artemisia annua
4.2.3.24 ATP more than 5fold reduction in enzyme activity at 15 mM ATP Artemisia annua
4.2.3.24 CTP potent inhibitor, 75fold inhibition at 10 mM Artemisia annua
4.2.3.24 diphosphate potent inhibitor Artemisia annua
4.2.3.24 additional information not inhibited by phosphomevalonic acid Artemisia annua

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.3.24 Mg2+ required Artemisia annua

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.24 (2E,6E)-farnesyl diphosphate Artemisia annua
-
 amorpha-4,11-diene + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.24 Artemisia annua
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.24 (2E,6E)-farnesyl diphosphate
-
 Artemisia annua amorpha-4,11-diene + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.24 ADS
-
 Artemisia annua

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.2.3.24 0.33
-
 at pH and °C Artemisia annua diphosphate