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Literature summary extracted from

  • Bhattacharjee, A.; Sinha, A.; Ratia, K.; Yin, L.; Delgado-Rivera, L.; Petukhov, P.A.; Thatcher, G.R.J.; Wardrop, D.J.
    2-Arylidene hydrazinecarbodithioates as potent, selective inhibitors of cystathionine gamma-lyase (CSE) (2017), ACS Med. Chem. Lett., 8, 1241-1245 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.4.1.1
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.1 2-(4-methoxyanilino)-2-oxoethyl-(2E)-2-[(3-fluoropyridin-2-yl)methylidene]hydrazine-1-carbodithioate compound shows at least 400fold selectivity for CSEgamma over inhibition of cystathionine beta-synthase Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.1 Homo sapiens P32929
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.1 L-cystathione + H2O
-
 Homo sapiens L-cysteine + NH3 + 2-oxobutanoate
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.4.1.1 0.0012
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-(4-methoxyanilino)-2-oxoethyl-(2E)-2-[(3-fluoropyridin-2-yl)methylidene]hydrazine-1-carbodithioate