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Literature summary extracted from

  • Zhang, Y.; den Braver-Sewradj, S.P.; Vos, J.C.; Vermeulen, N.P.E.; Commandeur, J.N.M.
    Human glutathione S-transferases- and NAD(P)H quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine Possible implications for susceptibility to amodiaquine-induced liver toxicity (2017), Toxicol. Lett., 275, 83-91 .
    View publication on PubMed

Application

EC Number Application Comment Organism
1.6.5.2 medicine low hepatic expression of the active glutathione S-transferases and NQO1 may increase the susceptibility of patients to amodiaquine idiosyncratic hepatotoxicity. NQO1 inactivates protein reactive quinonimines such as amodiaquine by reduction Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.6.5.2
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Homo sapiens P15559
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.6.5.2 280
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 amodiaquine + NAD+
-
Homo sapiens amodiaquine quinoneimine + NADH + H+
-
r
1.6.5.2 amodiaquine quinoneimine + NADH + H+
-
Homo sapiens amodiaquine + NAD+
-
r
1.6.5.2 N-desethylamodiaquine + NAD+
-
Homo sapiens N-desethylamodiaquine quinoneimine + NADH + H+
-
r
1.6.5.2 N-desethylamodiaquine quinoneimine + NADH + H+
-
Homo sapiens N-desethylamodiaquine + NAD+
-
r
1.6.5.2 oxidized dichlorophenolindophenol + NADH + H+
-
Homo sapiens reduced dichlorophenolindophenol + NAD+
-
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