EC Number | Application | Comment | Organism |
---|---|---|---|
1.6.5.2 | medicine | low hepatic expression of the active glutathione S-transferases and NQO1 may increase the susceptibility of patients to amodiaquine idiosyncratic hepatotoxicity. NQO1 inactivates protein reactive quinonimines such as amodiaquine by reduction | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.6.5.2 | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.5.2 | Homo sapiens | P15559 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.6.5.2 | liver | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.6.5.2 | 280 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.5.2 | amodiaquine + NAD+ | - |
Homo sapiens | amodiaquine quinoneimine + NADH + H+ | - |
r | |
1.6.5.2 | amodiaquine quinoneimine + NADH + H+ | - |
Homo sapiens | amodiaquine + NAD+ | - |
r | |
1.6.5.2 | N-desethylamodiaquine + NAD+ | - |
Homo sapiens | N-desethylamodiaquine quinoneimine + NADH + H+ | - |
r | |
1.6.5.2 | N-desethylamodiaquine quinoneimine + NADH + H+ | - |
Homo sapiens | N-desethylamodiaquine + NAD+ | - |
r | |
1.6.5.2 | oxidized dichlorophenolindophenol + NADH + H+ | - |
Homo sapiens | reduced dichlorophenolindophenol + NAD+ | - |
? |