Literature summary extracted from

Kostin, V.A.; Zolottsev, V.A.; Kuzikov, A.V.; Masamrekh, R.A.; Shumyantseva, V.V.; Veselovsky, A.V.; Stulov, S.V.; Novikov, R.A.; Timofeev, V.P.; Misharin, A.Y.
Oxazolinyl derivatives of [17(20)E]-21-norpregnene differing in the structure of A and B rings. Facile synthesis and inhibition of CYP17A1 catalytic activity (2016), Steroids, 115, 114-122 .

Application

EC Number	Application	Comment	Organism
1.14.14.19	analysis	assay based on direct electrochemistry of CYP17A1 entrapped in didodecyldimethyl ammonium bromide-modified electrode under aerobic conditions in the supporting electrolyte solution	Homo sapiens

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
1.14.14.19	molecular docking of inhibitors to the active site	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.14.19	2'-[[(E)-3-oxoandrost-4-en-17-ylidene]methyl]-4',5'-dihydro-1',3'-oxazole	1 microM, 54% inhibition	Homo sapiens
1.14.14.19	2'-[[(E)-3beta-hydroxyandrost-5-en-17-ylidene]methyl]-4',5'-dihydro-1',3'-oxazole	1 microM, 78% inhibition	Homo sapiens
1.14.14.19	2'-[[(E)-6-oxo-3alpha,5alpha-cycloandrostan-17-ylidene]methyl]-4',5'-dihydro-1',3'-oxazole	compound strongly depresses electrocatalytic activity of CYP17A1 toward pregnenolone at concentrations of 0.1 microM and 1 microM, but data do not obey the Michaelis-Menten catalytic model	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.19	Homo sapiens	P05093	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.19	pregnenolone + AH2 + O2	-	Homo sapiens	17alpha-hydroxypregnenolone + A + H2O	-	?

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Release 2023.1 (January 2023)