EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.18.1 | Ac-KSRFR | N-acetyl-pentapeptide Ac-P2, mixed-type inhibition | Agaricus bisporus | |
1.14.18.1 | Ac-KSSFR | N-acetyl-pentapeptide Ac-P3, mixed-type inhibition | Agaricus bisporus | |
1.14.18.1 | Ac-RSRFK | N-acetyl-pentapeptide Ac-P1, mixed-type inhibition | Agaricus bisporus | |
1.14.18.1 | Ac-RSRFS | N-acetyl-pentapeptide Ac-P4, mixed-type inhibition | Agaricus bisporus | |
1.14.18.1 | kojic acid | - |
Agaricus bisporus | |
1.14.18.1 | additional information | mushroom tyrosinase and melanogenesis inhibition by N-acetyl-pentapeptides, inhibition kinetics, overview. The compounds inhibits melanogenesis and reduce the melanin content, e.g. in murine B16F10 cells | Agaricus bisporus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.18.1 | 2 L-dopa + O2 | Agaricus bisporus | - |
2 dopaquinone + 2 H2O | - |
? | |
1.14.18.1 | tyrosine + O2 | Agaricus bisporus | - |
dopaquinone + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.18.1 | Agaricus bisporus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.18.1 | commercial preparation | - |
Agaricus bisporus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.18.1 | 2 L-dopa + O2 | - |
Agaricus bisporus | 2 dopaquinone + 2 H2O | - |
? | |
1.14.18.1 | tyrosine + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.18.1 | mushroom tyrosinase | - |
Agaricus bisporus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.18.1 | additional information | - |
additional information | inhibition kinetics, kinetic analysis of N-acetyl-pentapeptides, overview | Agaricus bisporus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.14.18.1 | 0.00029 | - |
pH 6.8, 25°C | Agaricus bisporus | Ac-RSRFS | |
1.14.18.1 | 0.00075 | - |
pH 6.8, 25°C | Agaricus bisporus | Ac-RSRFK | |
1.14.18.1 | 0.00078 | - |
pH 6.8, 25°C | Agaricus bisporus | Ac-KSRFR | |
1.14.18.1 | 0.00081 | - |
pH 6.8, 25°C | Agaricus bisporus | Ac-KSSFR |