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Literature summary extracted from

  • Chen, Y.; Terajima, M.; Banerjee, P.; Guo, H.; Liu, X.; Yu, J.; Yamauchi, M.; Kurie, J.M.
    FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch (2017), Sci. Rep., 7, 46021 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.4 FKBP65 FKBP65 interacts with LH2 through its peptidyl prolyl isomerase (PPIase) domains, FKBP65 forms a complex with LH2. Reconstitution with wild-type FKBP65 increases the enzyme activity by 7fold Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.4 endoplasmic reticulum
-
 Mus musculus 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.4 additional information Mus musculus FKBP65 interacts with LH2 through its peptidyl prolyl isomerase (PPIase) domains, FKBP65 forms a complex with LH2 ?
-
 ?
1.14.11.4 [procollagen]-L-lysine + 2-oxoglutarate + O2 Mus musculus
-
 [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.4 Mus musculus Q9R0B9
-
-
5.2.1.8 Mus musculus Q61576
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.4 embryo
-
 Mus musculus
-
1.14.11.4 fibroblast
-
 Mus musculus
-
1.14.11.4 MEF cell
-
 Mus musculus
-
5.2.1.8 fibroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.4 additional information FKBP65 interacts with LH2 through its peptidyl prolyl isomerase (PPIase) domains, FKBP65 forms a complex with LH2 Mus musculus ?
-
 ?
1.14.11.4 [procollagen]-L-lysine + 2-oxoglutarate + O2
-
 Mus musculus [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.4 LH2
-
 Mus musculus
1.14.11.4 lysyl hydroxylase 2
-
 Mus musculus
1.14.11.4 PLOD2
-
 Mus musculus
5.2.1.8 FkbP10
-
 Mus musculus
5.2.1.8 FKBP65
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.14.11.4 physiological function LH2 promotes fibrosis and cancer metastasis. Peptidyl prolyl isomerase (PPIase) activity of FKBP65 positively modulates LH2 enzymatic activity and is critical for the formation of hydroxylysine-aldehyde derived intermolecular collagen cross-links. FKBP65 regulates LH2-mediated collagen cross-linking. FKBP65 interacts with LH2 through its peptidyl prolyl isomerase (PPIase) domains, FKBP65 forms a complex with LH2. Reconstitution with wild-type FKBP65 increases the enzyme activity by 7fold Mus musculus
5.2.1.8 physiological function enzyme regulates lysyl hydroxylase LH2-mediated collagen cross-linking. FKBP65 deficiency diminishes hydroxylysine-aldehyde derived intermolecular collagen cross-links and increases the non-hydroxylated lysine-aldehyde-derived collagen cross-links Mus musculus