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Literature summary extracted from

  • Qiao, L.; Du, M.; Liang, X.; Hao, Y.; He, X.; Si, F.; Mei, T.; Chen, B.
    Tyrosine Hydroxylase is crucial for maintaining pupal tanning and immunity in Anopheles sinensis (2016), Sci. Rep., 6, 29835 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.16.2
-
 Anopheles sinensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 Anopheles sinensis
-
 L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.2 Anopheles sinensis A0A084W0Q1 strain WX-LS
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.2 cuticle
-
 Anopheles sinensis
-
1.14.16.2 pupa
-
 Anopheles sinensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2
-
 Anopheles sinensis L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.2 tyrosine hydroxylase
-
 Anopheles sinensis

Expression

EC Number Organism Comment Expression
1.14.16.2 Anopheles sinensis during pupal metamorphosis, enzyme expression is upregulated during the late stage of development up

General Information

EC Number General Information Comment Organism
1.14.16.2 malfunction suppression of enzyme expression results in cuticle tanning defects and impaired immunity with dramatically decreased survival rates and life spans of pupae Anopheles sinensis
1.14.16.2 physiological function the enzyme is crucial for maintaining pupal tanning and immunity in Anopheles sinensis Anopheles sinensis