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Literature summary extracted from

  • Castellano, I.; Migliaccio, O.; D'Aniello, S.; Merlino, A.; Napolitano, A.; Palumbo, A.
    Shedding light on ovothiol biosynthesis in marine metazoans (2016), Sci. Rep., 6, 21506 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.99.52 gene ovoA, multi-exonic gene with 18 exons, DNA and amino acid sequence analysis, sequence comparisons and phylogenetic analysis Strongylocentrotus purpuratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.52 L-histidine + L-cysteine + O2 Strongylocentrotus purpuratus
-
 S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.52 Strongylocentrotus purpuratus A0A7M7PQ98
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.52 egg sea urchin Strongylocentrotus purpuratus eggs contain high concentrations (in the mM range) of ovothiol C Strongylocentrotus purpuratus
-
1.14.99.52 embryo
-
 Strongylocentrotus purpuratus
-
1.14.99.52 additional information enzyme expression analysis Strongylocentrotus purpuratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.52 L-histidine + L-cysteine + O2
-
 Strongylocentrotus purpuratus S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.52 OvoA
-
 Strongylocentrotus purpuratus
1.14.99.52 SpOvoA
-
 Strongylocentrotus purpuratus

Expression

EC Number Organism Comment Expression
1.14.99.52 Strongylocentrotus purpuratus SpOvoA upstream region analysis reveals several metal and stress responsive elements, overview up

General Information

EC Number General Information Comment Organism
1.14.99.52 evolution OvoA evolved in most marine metazoans and was lost in bony vertebrates during the transition from the aquatic to terrestrial environment. Evolutionary history of OvoA in metazoans, overview Strongylocentrotus purpuratus
1.14.99.52 metabolism gene ovoA is involved in ovothiol biosynthesis Strongylocentrotus purpuratus