Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chen, Y.; Wang, S.; Yi, Z.; Tian, H.; Aliyari, R.; Li, Y.; Chen, G.; Liu, P.; Zhong, J.; Chen, X.; Du, P.; Su, L.; Qin, F.X.; Deng, H.; Cheng, G.
    Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms (2014), Sci. Rep., 4, 7242 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.99.38 expressed in Huh-7.5.1 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.99.38 H242Q/H243Q inactive Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.38 cholesterol + AH2 + O2 Homo sapiens
-
 25-hydroxycholesterol + A + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.38 Homo sapiens Q95992
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.38 cholesterol + AH2 + O2
-
 Homo sapiens 25-hydroxycholesterol + A + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.99.38 ? x * 35000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.14.99.38 CH25H
-
 Homo sapiens
1.14.99.38 cholesterol-25-hydroxylase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.99.38 physiological function the enzyme restricts hepatitis C virus replication not only through its enzyme activity to produce 25-hydroxycholesterol but also by targeting the NS5A protein leading to the selective inhibition of NS5A dimer formation Homo sapiens