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Literature summary extracted from

  • Shyam, R.; Gorusupudi, A.; Nelson, K.; Horvath, M.P.; Bernstein, P.S.
    RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye (2017), Proc. Natl. Acad. Sci. USA, 114, 10882-10887 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.3.3.22 structural docking shows that the epsilon ring of lutein fits into the active site of RPE65 close to the nonheme iron center Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.3.3.22 Iron nonheme iron center Homo sapiens
5.3.3.22 Iron nonheme iron center Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
5.3.3.22 Gallus gallus Q9YGX2 enzyme catalyzes both the isomerization of all-trans-retinyl esters to 11-cis-retinol in the vertebrate visual cycle, cf. EC. 3.1.1.64, and is responsible for the production of meso-zeaxanthin, i.e. (3R,3'S)-beta,beta-carotene-3,3'-diol in vertebrates
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5.3.3.22 Homo sapiens Q16518 enzyme catalyzes both the isomerization of all-trans-retinyl esters to 11-cis-retinol in the vertebrate visual cycle, cf. EC. 3.1.1.64, and is responsible for the production of meso-zeaxanthin, i.e. (3R,3'S)-beta,beta-carotene-3,3'-diol in vertebrates
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.3.22 eye
-
 Homo sapiens
-
5.3.3.22 eye
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.3.22 lutein
-
 Homo sapiens meso-zeaxanthin
-
 ?
5.3.3.22 lutein
-
 Gallus gallus meso-zeaxanthin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.3.22 Rpe65
-
 Homo sapiens
5.3.3.22 Rpe65
-
 Gallus gallus

Expression

EC Number Organism Comment Expression
5.3.3.22 Gallus gallus RNA is upregulated 23fold at the time of meso-zeaxanthin production during chicken eye development up

General Information

EC Number General Information Comment Organism
5.3.3.22 physiological function overexpression of RPE65 in cell culture leads to the production of meso-zeaxanthin from lutein Homo sapiens
5.3.3.22 physiological function overexpression of RPE65 in cell culture leads to the production of meso-zeaxanthin from lutein. Pharmacologic inhibition of RPE65 function results in significant inhibition of meso-zeaxanthin biosynthesis during chicken eye development Gallus gallus