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Literature summary extracted from

  • Zhu, Y.; Jameson, E.; Crosatti, M.; Schaefer, H.; Rajakumar, K.; Bugg, T.D.; Chen, Y.
    Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota (2014), Proc. Natl. Acad. Sci. USA, 111, 4268-4273 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.13.239 expressed in Escherichia coli BLR(DE3) pLysS cells Acinetobacter baumannii

Protein Variants

EC Number Protein Variants Comment Organism
1.14.13.239 E205A inactive Acinetobacter baumannii
1.14.13.239 E205D inactive Acinetobacter baumannii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.239 L-carnitine + NADH + H+ + O2 Acinetobacter baumannii
-
 (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
-
 ?
1.14.13.239 L-carnitine + NADH + H+ + O2 Acinetobacter baumannii ATCC19606
-
 (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
-
 ?
1.14.13.239 L-carnitine + NADPH + H+ + O2 Acinetobacter baumannii
-
 (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
-
 ?
1.14.13.239 L-carnitine + NADPH + H+ + O2 Acinetobacter baumannii ATCC19606
-
 (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.239 Acinetobacter baumannii D0C9N6 AND D0C9N8 alpha subunit and beta subunit
-
1.14.13.239 Acinetobacter baumannii ATCC19606 D0C9N6 AND D0C9N8 alpha subunit and beta subunit
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.13.239 His-tag affinity column chromatography Acinetobacter baumannii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.239 L-carnitine + NADH + H+ + O2
-
 Acinetobacter baumannii (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
-
 ?
1.14.13.239 L-carnitine + NADH + H+ + O2
-
 Acinetobacter baumannii ATCC19606 (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
-
 ?
1.14.13.239 L-carnitine + NADPH + H+ + O2
-
 Acinetobacter baumannii (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
-
 ?
1.14.13.239 L-carnitine + NADPH + H+ + O2
-
 Acinetobacter baumannii ATCC19606 (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.239 cntAB
-
 Acinetobacter baumannii

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.239 FAD
-
 Acinetobacter baumannii
1.14.13.239 NAD+
-
 Acinetobacter baumannii
1.14.13.239 NADH
-
 Acinetobacter baumannii
1.14.13.239 NADPH
-
 Acinetobacter baumannii
1.14.13.239 [2Fe-2S]-center
-
 Acinetobacter baumannii