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Literature summary extracted from

  • Tucker, A.C.; Escalante-Semerena, J.C.
    Determinants within the C-terminal domain of Streptomyces lividans acetyl-CoA synthetase that block acetylation of its active site lysine in vitro by the protein acetyltransferase (Pat) enzyme (2014), PLoS ONE, 9, e99817 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.1 expressed in Escherichia coli C41(DE3) cells Salmonella enterica
6.2.1.1 expressed in Escherichia coli C41(DE3) cells Streptomyces lividans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.1 ATP + acetate + CoA Salmonella enterica
-
 AMP + diphosphate + acetyl-CoA
-
 ?
6.2.1.1 ATP + acetate + CoA Streptomyces lividans
-
 AMP + diphosphate + acetyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.1 Salmonella enterica
-
-
-
6.2.1.1 Streptomyces lividans
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.2.1.1 acetylation
-
 Salmonella enterica
6.2.1.1 acetylation the enzyme is poorly acetylated in vitro by the Streptomyces lividans protein acetyltransferase Pat Streptomyces lividans

Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.1
-
 Salmonella enterica
6.2.1.1
-
 Streptomyces lividans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.1 ATP + acetate + CoA
-
 Salmonella enterica AMP + diphosphate + acetyl-CoA
-
 ?
6.2.1.1 ATP + acetate + CoA
-
 Streptomyces lividans AMP + diphosphate + acetyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.1 Acetyl-CoA synthetase
-
 Salmonella enterica
6.2.1.1 Acetyl-CoA synthetase
-
 Streptomyces lividans
6.2.1.1 ACS
-
 Salmonella enterica
6.2.1.1 ACS
-
 Streptomyces lividans
6.2.1.1 Acyl-CoA synthetase
-
 Salmonella enterica
6.2.1.1 Acyl-CoA synthetase
-
 Streptomyces lividans
6.2.1.1 AMP-forming CoA ligase
-
 Salmonella enterica
6.2.1.1 AMP-forming CoA ligase
-
 Streptomyces lividans

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.1 ATP
-
 Salmonella enterica
6.2.1.1 ATP
-
 Streptomyces lividans