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Literature summary extracted from

  • D, J.J.; Dhanraj, M.; Solaiappan, S.; Sivanesan, S.; Kron, M.; Dhanasekaran, A.
    Brugia malayi asparaginyl-tRNA synthetase stimulates endothelial cell proliferation, vasodilation and angiogenesis (2016), PLoS ONE, 11, e0146132 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.1.1.22 expressed in Escherichia coli BL21(DE3) cells Brugia malayi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.22 ATP + L-asparagine + tRNAAsn Brugia malayi
-
 AMP + diphosphate + L-asparaginyl-tRNAAsn
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.22 Brugia malayi
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.1.1.22 immobilized metal-affinity chromatography Brugia malayi

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.22 ATP + L-asparagine + tRNAAsn
-
 Brugia malayi AMP + diphosphate + L-asparaginyl-tRNAAsn
-
 ?

Subunits

EC Number Subunits Comment Organism
6.1.1.22 ? x * 63000, His6-tagged enzyme, SDS-PAGE Brugia malayi

Synonyms

EC Number Synonyms Comment Organism
6.1.1.22 AsnRS
-
 Brugia malayi
6.1.1.22 Asparaginyl-tRNA synthetase
-
 Brugia malayi

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.22 ATP
-
 Brugia malayi

General Information

EC Number General Information Comment Organism
6.1.1.22 physiological function the enzyme induces endothelial cell proliferation, promotes chemotaxis and induces ring formation and tube formation by EA.hy926 cells. The enzyme induces vasodilation in chick embryo chorioallantoic membranes Brugia malayi