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Literature summary extracted from

  • Francis, W.R.; Shaner, N.C.; Christianson, L.M.; Powers, M.L.; Haddock, S.H.
    Occurrence of isopenicillin-N-synthase homologs in bioluminescent ctenophores and implications for coelenterazine biosynthesis (2015), PLoS ONE, 10, e0128742 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Mycolicibacterium phlei
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Gordonia rubripertincta
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Aspergillus nidulans
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Streptomyces microflavus
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Streptomyces cattleya
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Penicillium chrysogenum
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Acremonium chrysogenum
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Amycolatopsis lactamdurans
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Crassostrea gigas
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Streptomyces clavuligerus
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Lysobacter lactamgenus
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Flavobacterium sp. SC 12154
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Streptomyces griseus
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Streptomyces jumonjinensis
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Mycolicibacterium phlei RIVM601174
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Aspergillus nidulans ATCC 38163
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Streptomyces clavuligerus ATCC 27064
-
 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 Gordonia rubripertincta NBRC 101908
-
 isopenicillin N + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.3.1 Acremonium chrysogenum P05189
-
-
1.21.3.1 Amycolatopsis lactamdurans P27744
-
-
1.21.3.1 Aspergillus nidulans P05326
-
-
1.21.3.1 Aspergillus nidulans ATCC 38163 P05326
-
-
1.21.3.1 Crassostrea gigas K1QF46
-
-
1.21.3.1 Flavobacterium sp. SC 12154 P16020
-
-
1.21.3.1 Gordonia rubripertincta
-
-
-
1.21.3.1 Gordonia rubripertincta NBRC 101908
-
-
-
1.21.3.1 Lysobacter lactamgenus Q48739
-
-
1.21.3.1 Mycolicibacterium phlei
-
-
-
1.21.3.1 Mycolicibacterium phlei RIVM601174
-
-
-
1.21.3.1 Penicillium chrysogenum P08703
-
-
1.21.3.1 Streptomyces cattleya Q53932
-
-
1.21.3.1 Streptomyces clavuligerus P10621
-
-
1.21.3.1 Streptomyces clavuligerus ATCC 27064 P10621
-
-
1.21.3.1 Streptomyces griseus Q54243
-
-
1.21.3.1 Streptomyces jumonjinensis P18286
-
-
1.21.3.1 Streptomyces microflavus P12438
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Mycolicibacterium phlei isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Gordonia rubripertincta isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Aspergillus nidulans isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Streptomyces microflavus isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Streptomyces cattleya isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Penicillium chrysogenum isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Acremonium chrysogenum isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Amycolatopsis lactamdurans isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Crassostrea gigas isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Streptomyces clavuligerus isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Lysobacter lactamgenus isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Flavobacterium sp. SC 12154 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Streptomyces griseus isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Streptomyces jumonjinensis isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Mycolicibacterium phlei RIVM601174 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Aspergillus nidulans ATCC 38163 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Streptomyces clavuligerus ATCC 27064 isopenicillin N + H2O
-
 ?
1.21.3.1 N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
-
 Gordonia rubripertincta NBRC 101908 isopenicillin N + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.3.1 IPNS
-
 Mycolicibacterium phlei
1.21.3.1 IPNS
-
 Gordonia rubripertincta
1.21.3.1 IPNS
-
 Aspergillus nidulans
1.21.3.1 IPNS
-
 Streptomyces microflavus
1.21.3.1 IPNS
-
 Streptomyces cattleya
1.21.3.1 IPNS
-
 Penicillium chrysogenum
1.21.3.1 IPNS
-
 Acremonium chrysogenum
1.21.3.1 IPNS
-
 Amycolatopsis lactamdurans
1.21.3.1 IPNS
-
 Crassostrea gigas
1.21.3.1 IPNS
-
 Streptomyces clavuligerus
1.21.3.1 IPNS
-
 Lysobacter lactamgenus
1.21.3.1 IPNS
-
 Flavobacterium sp. SC 12154
1.21.3.1 IPNS
-
 Streptomyces griseus
1.21.3.1 IPNS
-
 Streptomyces jumonjinensis
1.21.3.1 isopenicillin-N-synthase
-
 Mycolicibacterium phlei
1.21.3.1 isopenicillin-N-synthase
-
 Gordonia rubripertincta
1.21.3.1 isopenicillin-N-synthase
-
 Aspergillus nidulans
1.21.3.1 isopenicillin-N-synthase
-
 Streptomyces microflavus
1.21.3.1 isopenicillin-N-synthase
-
 Streptomyces cattleya
1.21.3.1 isopenicillin-N-synthase
-
 Penicillium chrysogenum
1.21.3.1 isopenicillin-N-synthase
-
 Acremonium chrysogenum
1.21.3.1 isopenicillin-N-synthase
-
 Amycolatopsis lactamdurans
1.21.3.1 isopenicillin-N-synthase
-
 Crassostrea gigas
1.21.3.1 isopenicillin-N-synthase
-
 Streptomyces clavuligerus
1.21.3.1 isopenicillin-N-synthase
-
 Lysobacter lactamgenus
1.21.3.1 isopenicillin-N-synthase
-
 Flavobacterium sp. SC 12154
1.21.3.1 isopenicillin-N-synthase
-
 Streptomyces griseus
1.21.3.1 isopenicillin-N-synthase
-
 Streptomyces jumonjinensis