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Literature summary extracted from

  • Lavado-Roldan, A.; Fernandez-Chacon, R.
    Two for the price of one a neuroprotective chaperone kit within NAD synthase protein NMNAT2 (2016), PLoS Biol., 14, e1002522 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.1 cytosol
-
 Homo sapiens 5829
-
2.7.7.1 Golgi vesicle
-
 Homo sapiens
-
-
2.7.7.1 additional information in vertebrates, the isoform NMNAT2 functions as a cytosolic protein bound to Golgi-derived vesicles through the palmitoylation of several cysteine residues Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide Homo sapiens
-
 diphosphate + NAD+
-
 ?
2.7.7.1 additional information Homo sapiens NMNAT2 complexes with heat shock protein 90 (HSP90) ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Homo sapiens Q9BZQ4
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.7.1 lipoprotein in vertebrates, the isoform NMNAT2 functions as a cytosolic protein bound to Golgi-derived vesicles through the palmitoylation of several cysteine residues Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.1 brain in vertebrates, the isoform NMNAT2 is highly expressed in the brain Homo sapiens
-
2.7.7.1 neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Homo sapiens diphosphate + NAD+
-
 ?
2.7.7.1 additional information NMNAT2 complexes with heat shock protein 90 (HSP90) Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.1 NAD synthase
-
 Homo sapiens
2.7.7.1 nicotinamide mononucleotide adenylyltransferase 2
-
 Homo sapiens
2.7.7.1 NMNAT2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.7.1 physiological function the enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) acts not only as a NAD synthase involved in axonal maintenance but as a molecular chaperone helping neurons to overcome protein unfolding and protein aggregation, molecular mechanism, overview. NMNAT2 acts as a molecular chaperone that cooperates with HSP90 to refold denatured proteins (foldase activity) and independently prevents protein unfolding (holdase activity). In vertebrates, the isoform NMNAT2, highly expressed in the brain, functions as a cytosolic protein bound to Golgi-derived vesicles through the palmitoylation of several cysteine residues. NMNAT2 seems to be essential for axonal growth or maintenance during embryogenesis. Enzyme NMNAT2 complexes with heat shock protein 90 (HSP90), an abundant and ubiquitous molecular chaperone that plays an essential role in maintaining protein homeostasis Homo sapiens